STABLE CRYSTAL FORM OF TIPIRACIL HYDROCHLORIDE AND CRYSTALLIZATION METHOD FOR THE SAME
    1.
    发明公开
    STABLE CRYSTAL FORM OF TIPIRACIL HYDROCHLORIDE AND CRYSTALLIZATION METHOD FOR THE SAME 审中-公开
    盐酸噻拉西林的稳定结晶形式及其结晶方法

    公开(公告)号:EP3305779A1

    公开(公告)日:2018-04-11

    申请号:EP17204730.0

    申请日:2014-06-17

    CPC分类号: C07D403/06 C07B2200/13

    摘要: An objective of the present invention is to obtain a stable crystal form of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrim idinedione hydrochloride. The present invention provides a crystal of 5-chloro-6-(2-iminopyrrolidin-l-yl)methyl-2,4(1H,3H)-pyrim idinedione hydrochloride exhibiting characteristic peaks at angles of 11.6°, 17.2°, 17.8°, 23.3°, 27.1°, and 29.3° as a diffraction angle (2θ ± 0.1°) in powder X-ray diffraction.

    摘要翻译: 本发明的目的是获得5-氯-6-(2-亚氨基吡咯烷-1-基)甲基-2,4(1H,3H) - 嘧啶酮二酮盐酸盐的稳定晶型。 本发明提供了在11.6°,17.2°,17.8°角具有特征峰的5-氯-6-(2-亚氨基吡咯烷-1-基)甲基-2,4(1H,3H) - 嘧啶二酮盐酸盐的晶体 ,23.3°,27.1°和29.3°作为粉末X射线衍射中的衍射角(2θ±0.1°)。