公开(公告)号：EP2763673A1

公开(公告)日：2014-08-13

申请号：EP12831877.1

申请日：2012-09-15

申请人： Taipei Medical University

发明人： CHEN, Yi-Jen ,  HUNG, Kuo-Sheng ,  KAO, Yu-Hsun ,  LIOU, Jing-Ping ,  SHAN, Pei-Wen

IPC分类号： A61K31/404

CPC分类号： C07D209/30 ,  A61K31/404 ,  C07D209/08 ,  C07D209/18

摘要： Novel use of small molecules, particularly indolyl and indolinyl hydroxamates is disclosed herein. The indolyl and indolinyl hydroxamates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient suffering from heart failure or neuronal injury.

公开(公告)号：EP2552887B1

公开(公告)日：2018-10-24

申请号：EP11766447.4

申请日：2011-03-29

申请人： Taipei Medical University ,  Ohio State University ,  National Taiwan University

发明人： CHEN, Ching-Shih ,  LIOU, Jing-Ping ,  LIU, Hsing-Jin ,  HUNG, Kuo-Sheng ,  SHAN, Pei-Wen ,  CHIU, Wen-Ta ,  TENG, Che-Ming

IPC分类号： C07D209/20 ,  C07D209/18 ,  C07D209/22 ,  C07D209/12 ,  A61K31/404 ,  A61P35/00

CPC分类号： C07D209/08 ,  C07D209/12 ,  C07D209/18 ,  C07D209/30 ,  C07D209/40

摘要： Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.

公开(公告)号：EP2763673B1

公开(公告)日：2018-08-01

申请号：EP12831877.1

申请日：2012-09-15

申请人： Taipei Medical University

发明人： CHEN, Yi-Jen ,  HUNG, Kuo-Sheng ,  KAO, Yu-Hsun ,  LIOU, Jing-Ping ,  SHAN, Pei-Wen

IPC分类号： A61K31/404 ,  A61P9/00 ,  A61P25/00

CPC分类号： C07D209/30 ,  A61K31/404 ,  C07D209/08 ,  C07D209/18

摘要： Novel use of small molecules, particularly indolyl and indolinyl hydroxamates is disclosed herein. The indolyl and indolinyl hydroxamates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient suffering from heart failure or neuronal injury.

公开(公告)号：EP2552887A2

公开(公告)日：2013-02-06

申请号：EP11766447.4

申请日：2011-03-29

申请人： Taipei Medical University ,  Ohio State University ,  National Taiwan University

发明人： CHEN, Ching-Shih ,  LIOU, Jing-Ping ,  LIU, Hsing-Jin ,  HUNG, Kuo-Sheng ,  SHAN, Pei-Wen ,  CHIU, Wen-Ta ,  TENG, Che-Ming

IPC分类号： C07D209/20 ,  C07D209/18 ,  C07D209/22 ,  C07D209/12 ,  A61K31/404 ,  A61P35/00

CPC分类号： C07D209/08 ,  C07D209/12 ,  C07D209/18 ,  C07D209/30 ,  C07D209/40

摘要： Described herein are indolyl or indolinyl hydroxamates and pharmaceutical compositions comprising the same, which show histone diacetylase (HDAC) inhibition activity. Also disc a method for treating cancer with these compounds.