公开(公告)号：EP1464335A3

公开(公告)日：2007-05-09

申请号：EP04007651.5

申请日：2004-03-30

申请人： Taisho Pharmaceutical Co. Ltd. ,  Arena Pharmaceuticals, Inc.

发明人： Sekiguchi, Yoshinori Taisho Pharmaceutical Co. Ltd ,  Kanuma, Kosuke Taisho Pharmaceutical Co. Ltd ,  Omodera, Katsunori Taisho Pharmaceutical Co. Ltd ,  Busujima, Tsuyoshi Taisho Pharmaceutical Co. Ltd ,  Tran, Thuy-Anh ,  Han, Sangdon ,  Casper, Martin ,  Kramer, Bryan A. ,  Semple, Graeme ,  Zou, Ning

IPC分类号： A61K31/4709 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D215/38 ,  A61K31/506 ,  A61P3/04

CPC分类号： C07D239/48 ,  C07D215/42 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to compounds of the Formula (I)

wherein Q is:

which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

公开(公告)号：EP1464335A2

公开(公告)日：2004-10-06

申请号：EP04007651.5

申请日：2004-03-30

申请人： Taisho Pharmaceutical Co. Ltd. ,  Arena Pharmaceuticals, Inc.

发明人： Sekiguchi, Yoshinori Taisho Pharmaceutical Co. Ltd ,  Kanuma, Kosuke Taisho Pharmaceutical Co. Ltd ,  Omodera, Katsunori Taisho Pharmaceutical Co. Ltd ,  Busujima, Tsuyoshi Taisho Pharmaceutical Co. Ltd ,  Tran, Thuy-Anh ,  Han, Sangdon ,  Casper, Martin ,  Kramer, Bryan A. ,  Semple, Graeme ,  Zou, Ning

IPC分类号： A61K31/4709 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D215/38 ,  A61K31/506 ,  A61P3/04

CPC分类号： C07D239/48 ,  C07D215/42 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to compounds of the Formula (I)
wherein Q is:
which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

摘要翻译： 本发明涉及式（I）的化合物，其中Q为：其作为MCH受体拮抗剂。 这些组合物可用于药物组合物，其用途包括预防或治疗改善记忆功能，睡眠和觉醒，焦虑，抑郁，情绪障碍，癫痫发作，肥胖症，糖尿病，食欲和进食障碍，心血管疾病，高血压，血脂异常，心肌梗死， 包括贪食症，厌食症，包括躁狂抑郁症，精神分裂症，del妄，痴呆，压力，认知障碍，注意力缺陷障碍，药物滥用障碍和运动障碍，包括帕金森氏病，癫痫症和成瘾症的暴饮暴食症。