利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.02 秒)

    Cyclohexanol derivatives, production and use thereof
    3.
    发明公开
    Cyclohexanol derivatives, production and use thereof 失效
    Cyclohexanolderivate，ihre Herstellung und ihre Verwendung。

    公开(公告)号：EP0415294A2

    公开(公告)日：1991-03-06

    申请号：EP90116309.7

    申请日：1990-08-25

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Kishimoto, Shoji ,  Marui, Shogo ,  Fujita, Takeshi

    IPC分类号： C07D303/22 ,  C07D303/34 ,  C07D303/36 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  A61K31/335

    CPC分类号： C07D303/22 ,  C07D303/34 ,  C07D303/36 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  Y10S514/825 ,  Y10S514/863 ,  Y10S514/866

    摘要： The present invention relates to a compound of the formula:
    wherein A is halogen, N(O)mR¹R², N ⊕ R¹R²R³·X ⊖ , S(O)nR¹ or S ⊕ (O)mR¹R²·X ⊖ where R¹,R² and R³ are each optionally substituted hydrocarbon or heterocyclic group, X ⊖ is a counter anion; m is an integer of 0 or 1; n is an integer of 0 to 2; R¹ and R² may form a nitrogen-­containing or a sulfur-containing heterocyclic ring, which may further form a condensed ring, with the adjacent nitrogen atom or sulfur atom, and these nitrogen-containing or sulfur-containing heterocyclic rings may have substituents, B is O or NR⁴ where R⁴ is hydrogen or an optionally substituted lower alkyl or aryl group, D is 2-methyl-1-propenyl group or isobutyl group, and E is hydrogen, an optionally substituted hydrocarbon or an optionally substituted acyl group; provided that, when A is chlorine, E is an optionally substituted hydrocarbon or acyl excepting dinitrobenzoyl, a salt thereof, production and use thereof.
    The novel cyclohexanol derivatives of the present invention have angiogenesis inhibiting activity and anti-tumor activity, and they are used as anti-­rheumatic agents, therapeutic agents of psoriasis, therapeutic agents of diabetic retinopathy and anti-­tumor agents.

    摘要翻译： 本发明涉及下式化合物：其中A为卤素，N（O）m R 1 R 2，N（R）R 1 R 2 R 3， ，X（=），S（O）nR 1或S（（+））（O）m R 1 R 2，X（ - ））其中R 1，R 2 >和R 3各自是任选取代的烃或杂环基，X'（ - ）>是抗衡阴离子; m为0或1的整数; n为0〜2的整数， R 1和R 2可以形成含氮或含硫杂环，其可以与相邻的氮原子或硫原子进一步形成稠环，并且这些含氮或含硫杂环 环可以具有取代基，B是O或NR 4，其中R 4是氢或任选取代的低级烷基或芳基，D是2-甲基-1-丙烯基或异丁基，E是氢， 任选取代的烃或任选取代的酰基; 条件是当A是氯时，E是除二硝基苯甲酰基以外的任选取代的烃或酰基，其盐，其制备和用途。 本发明的新型环己醇衍生物具有血管生成抑制活性和抗肿瘤活性，并且它们用作抗风湿剂，牛皮癣治疗剂，糖尿病性视网膜病变的治疗剂和抗肿瘤剂。

    Imidazole derivatives as glutaminose inhibitors
    5.
    发明公开
    Imidazole derivatives as glutaminose inhibitors 失效
    咪唑啉酮谷氨酰胺酶。

    公开(公告)号：EP0656210A1

    公开(公告)日：1995-06-07

    申请号：EP94118069.7

    申请日：1994-11-16

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Matsutani, Etsuya ,  Marui, Shogo

    IPC分类号： A61K31/415 ,  C07D233/88

    CPC分类号： C07D233/88 ,  A61K31/415

    摘要： There is disclosed a pharmaceutical composition for inhibiting glutaminase which comprises a imidazole derivative or a salt thereof. This compound selectively inhibits the proliferation of tumor cells, and the composition is useful as an anti-cancer agent. There is also disclosed a novel imidazole derivative having glutaminase inhibitory activity.

    摘要翻译： 公开了一种抑制谷氨酰胺酶的药物组合物，其包含咪唑衍生物或其盐。 该化合物选择性地抑制肿瘤细胞的增殖，该组合物可用作抗癌剂。 还公开了具有谷氨酰胺酶抑制活性的新型咪唑衍生物。

    Cyclohexanol derivatives, production and use thereof
    7.
    发明公开
    Cyclohexanol derivatives, production and use thereof 失效
    环辛醇衍生物，生产和使用

    公开(公告)号：EP0415294A3

    公开(公告)日：1991-06-12

    申请号：EP90116309.7

    申请日：1990-08-25

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Kishimoto, Shoji ,  Marui, Shogo ,  Fujita, Takeshi

    IPC分类号： C07D303/22 ,  C07D303/34 ,  C07D303/36 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  A61K31/335

    CPC分类号： C07D303/22 ,  C07D303/34 ,  C07D303/36 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  Y10S514/825 ,  Y10S514/863 ,  Y10S514/866

    摘要： The present invention relates to a compound of the formula:
    wherein A is halogen, N(O)mR¹R², N ⊕ R¹R²R³·X ⊖ , S(O)nR¹ or S ⊕ (O)mR¹R²·X ⊖ where R¹,R² and R³ are each optionally substituted hydrocarbon or heterocyclic group, X ⊖ is a counter anion; m is an integer of 0 or 1; n is an integer of 0 to 2; R¹ and R² may form a nitrogen-­containing or a sulfur-containing heterocyclic ring, which may further form a condensed ring, with the adjacent nitrogen atom or sulfur atom, and these nitrogen-containing or sulfur-containing heterocyclic rings may have substituents, B is O or NR⁴ where R⁴ is hydrogen or an optionally substituted lower alkyl or aryl group, D is 2-methyl-1-propenyl group or isobutyl group, and E is hydrogen, an optionally substituted hydrocarbon or an optionally substituted acyl group; provided that, when A is chlorine, E is an optionally substituted hydrocarbon or acyl excepting dinitrobenzoyl, a salt thereof, production and use thereof. The novel cyclohexanol derivatives of the present invention have angiogenesis inhibiting activity and anti-tumor activity, and they are used as anti-­rheumatic agents, therapeutic agents of psoriasis, therapeutic agents of diabetic retinopathy and anti-­tumor agents.

    6-Amino-6-desoxyfumagillols, production and use thereof
    8.
    发明公开
    6-Amino-6-desoxyfumagillols, production and use thereof 失效
    6-Amino-6-desoxyfumagillole，ihre Herstellung und ihre Verwendung。

    公开(公告)号：EP0386667A1

    公开(公告)日：1990-09-12

    申请号：EP90104176.4

    申请日：1990-03-03

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Kishimoto, Shoji ,  Marui, Shogo ,  Fujita, Takeshi

    IPC分类号： C07D303/36 ,  A61K31/335 ,  C07D405/04

    CPC分类号： C07D405/04 ,  C07D303/36

    摘要： The present invention relates to a compound of the formula:
    wherein R¹ is 2-methyl-1-propenyl group or isobutyl group; R² and R³ are each hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted acyl group or R² and R³ may form a ring together with the adjacent nitrogen atom; and the bonding mark ∼ means α-linkage or β-linkage, or a salt thereof.
    The compound (I) of the present invention has, among others, angiogenesis inhibiting activity, cell-­growth inhibiting activity and immune reaction inhibiting activity, thus being useful as medicines, etc.

    摘要翻译： 本发明涉及下式的化合物：其中R 1为2-甲基-1-丙烯基或异丁基; R 2和R 3各自为氢原子，任选取代的烃残基或任选取代的酰基，或R 2和R 3可以与相邻的氮原子一起形成环; 并且粘合标记是指α-链接或β-连接，或其盐。 本发明的化合物（I）具有血管生成抑制活性，细胞生长抑制活性和免疫反应抑制活性，作为药物等有用。