利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.019 秒)

    2-Oxoazetidine derivatives, their production and use
    4.
    发明公开
    2-Oxoazetidine derivatives, their production and use 失效
    2-Oxoazetidin-Derivate，ihre Herstellung und Verwendung。

    公开(公告)号：EP0053815A1

    公开(公告)日：1982-06-16

    申请号：EP81110154.2

    申请日：1981-12-04

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Matsuo, Taisuke ,  Masuya, Hirotomo ,  Noguchi, Noriyoshi ,  Michihiko, Ochiai

    IPC分类号： C07D205/08 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07F7/10 ,  A61K31/395

    CPC分类号： C07D205/085 ,  C07D205/095 ,  C07F7/0812 ,  C07F7/10 ,  C07F9/568 ,  Y02P20/55

    摘要： 1-Sulfo-2-oxoazetidine derivatives of the general formula (I)
    wherein R 1 is amino group which may optionally be acyiated or protected, X is hydrogen or methoxy, and R 4 is azido, a haiogen, amino group which may optionally be acylated or a group of the formula -OR 5 ,

    or -S-S-R 5 in which R s is an organic residue and n is 0,1 or 2, or a pharmaceutically acceptable salt thereof, or an ester thereof as well as methods of production in accordance with the following schemes:

    wherein R 2 is an acylated or protected amino group, R 3 is an acylated amino group, and R 1 and R 4 are as above defined. The compounds [I] have antimicrobial and β-lactamase inhibitory activity.

    摘要翻译： 通式（I）的1-磺基-2-氧代氮杂环丁啶衍生物... 其中R 1是任选被酰基或保护的氨基，X是氢或甲氧基，R 4是叠氮基，卤素，氨基， 可以任选地被酰化或者其中R 5是有机残基且n是0,1或2，或其药学上可接受的盐或其酯的式-OR 5，... CH 2或-SS-R 5的基团 以及根据以下方案的生产方法：... 其中R2是酰化或保护的氨基，R3是酰化氨基，R1和R4如上所定义。 化合物[I]具有抗微生物和β-内酰胺酶抑制活性。

    Method of preparing 1-sulfo-2-oxoazetidine derivatives and intermediates therefor
    6.
    发明公开
    Method of preparing 1-sulfo-2-oxoazetidine derivatives and intermediates therefor 失效
    Verfahren zur Herstellung von 1-Sulfo-2-oxoazetidin-Derivaten und die Zwischenprodukte。

    公开(公告)号：EP0053387A1

    公开(公告)日：1982-06-09

    申请号：EP81110039.5

    申请日：1981-12-01

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Matsuo, Taisuke ,  Masuya, Hirotomo ,  Noguchi, Noriyoshi ,  Ochiai, Michihiko

    IPC分类号： C07D205/08 ,  C07F7/10 ,  C07D417/12

    CPC分类号： C07D205/085 ,  C07D205/095 ,  C07F7/10 ,  Y02P20/55

    摘要： 1-Sulfo-2-oxoazetidine derivatives represented by the formula (I)
    wherein R, stands for an amino group which may optionally be acylated or protected, and X stands for hydrogen or methoxy, is produced by subjected a 1-t-butyl or isopropylsilyl derivative of a compound represented by the formula (II)
    wherein R 2 stands for an amino group which is acylated or protected, and X is of the same meaning as defined above, to sulfonation, followed by, when R 2 is a protected amino group, removing the protective group, if necessary.
    The compounds represented by the formula (I) have an excellent antibacterial and β-lactamase-inhibitory activity, thus being useful as drugs for humans and domestic animals.

    摘要翻译： 由式（I）表示的1-磺基-2-氧代氮杂环丁烷衍生物其中R1代表任选被酰化或保护的氨基，X代表氢或甲氧基，是通过使1-t- 式（II）表示的化合物的丁基或异丙基甲硅烷基衍生物其中R2表示被酰化或保护的氨基，X与上述定义相同，表示磺酸化，其后，当R 2为 被保护的氨基，必要时除去保护基。 由式（I）表示的化合物具有优异的抗细菌和β-内酰胺酶抑制活性，因此可用作人和家畜的药物。