公开(公告)号：EP1445254A1

公开(公告)日：2004-08-11

申请号：EP02778097.2

申请日：2002-11-12

申请人： Takeda Chemical Industries, Ltd.

发明人： TAWADA, Hiroyuki ,  YAMASHITA, Makoto ,  IKEMOTO, Tomomi ,  NISHIGUCHI, Atsuko

IPC分类号： C07D231/20 ,  C07D417/12 ,  C07D413/12 ,  C07D401/12 ,  C07D413/14

CPC分类号： C07D401/12 ,  C07D231/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： As a method capable of conveniently producing a pyrazole compound in a high yield, which is useful as a synthetic intermediate for a pharmaceutical agent such as a therapeutic agent for diabetes and the like, a production method of a compound represented by the formula (I)
wherein n is an integer of 1 to 4 and R 1 is a hydrocarbon group optionally having substituents, or a salt thereof, is provided, which includes reacting a compound represented by the formula (II)
wherein Q is a hydroxy group optionally having substituents or an amino group optionally having substituents, R is a hydrocarbon group optionally having substituents and other symbols are as defined above, or a salt thereof, with hydrazine or a salt thereof.

摘要翻译： 作为能够以高收率制备吡唑化合物的方法，其可用作糖尿病治疗剂等药剂的合成中间体，由式（I）表示的化合物的制造方法， 其中n为1〜4的整数，R 1为任选具有取代基的烃基或其盐，其包括使式（II）表示的化合物反应其中Q 是任选具有取代基的羟基或任选具有取代基的氨基，R是任选具有取代基的烃基，其它符号如上所定义，或其盐与肼或其盐。