公开(公告)号：EP2975023B1

公开(公告)日：2018-05-30

申请号：EP14763790.4

申请日：2014-03-13

申请人： Takeda Pharmaceutical Company Limited

发明人： FUJIYASU, Jiro ,  ASANO, Toru ,  YAMAKI, Susumu ,  KANEKO, Osamu ,  KOIKE, Yuka ,  IMAIZUMI, Tomoyoshi ,  URANO, Yasuharu ,  SATOU, Tomohki ,  SASAMURA, Satoshi

IPC分类号： C07D333/40 ,  C07C279/18 ,  C07D307/81 ,  C07D333/68 ,  C07D333/70 ,  C07D217/26 ,  C07D333/24 ,  A61K31/381 ,  A61K31/24 ,  A61K31/343 ,  A61K31/472 ,  A61P13/12

CPC分类号： C07D333/70 ,  A61K31/24 ,  A61K31/343 ,  A61K31/381 ,  A61K31/472 ,  C07C279/18 ,  C07C2602/08 ,  C07C2602/10 ,  C07D217/26 ,  C07D307/81 ,  C07D333/24 ,  C07D333/40 ,  C07D333/68

摘要： [Problem] To provide a compound which is useful as an agent for preventing and/or treating kidney diseases. [Means for Solution] The present inventors have studied compounds having a trypsin inhibitory activity, and have confirmed that a guanidinobenzoic acid ester compound has a trypsin inhibitory activity, thereby completing the present invention. The guanidinobenzoic acid ester compound of the present invention can be used as an agent for preventing and/or treating kidney diseases (for example, chronic kidney disease, acute glomerulonephritis, acute kidney injury, and the like) as an agent which will substitute low-protein diet therapy, and/or as an agent for preventing and/or treating trypsin-related diseases (for example, chronic pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like).