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公开(公告)号：EP4183411A1
公开(公告)日：2023-05-24
申请号：EP22204593.2
申请日：2014-03-12
申请人： Takeda Vaccines, Inc. , The Government of The United States of America as represented by The Secretary of The Department of Health and Human Services
IPC分类号： A61K39/12
摘要： Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) or dengue-4 (DEN-4) virus constructs. In other embodiments, constructs disclosed herein can be combined in a composition to generate a vaccine against more one or more dengue virus constructs that may or may not be subsequently passaged in mammalian cells.
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公开(公告)号：EP3603667A1
公开(公告)日：2020-02-05
申请号：EP19172758.5
申请日：2014-03-13
发明人： STINCHCOMB, Dan , LIVENGOOD, Jill , VARGA, Laszlo
IPC分类号： A61K39/12
摘要： Embodiments herein relate to compositions of and methods for live attenuated alphaviruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated alphaviruses and compositions to reduce inactivation and/or degradation of the live, attenuated alphavirus. In other embodiments, the live, attenuated virus composition may be a vaccine composition. In yet other compositions, a live, attenuated alphavirus composition may include HEPES buffer. In other embodiments, the HEPES buffer may further include a carbohydrate and gelatin and/or a salt.
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公开(公告)号：EP4154003A1
公开(公告)日：2023-03-29
申请号：EP21725278.2
申请日：2021-03-19
发明人： LIVENGOOD, Jill , JOHNSON, Michael , GIFFORD, James , NEAD, Tawnya , LYONS, Mark , MARKS, Jackie
IPC分类号： G01N33/542 , G01N33/533 , G01N33/569 , A61K39/12
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