公开(公告)号：EP3606559A1

公开(公告)日：2020-02-12

申请号：EP18721547.0

申请日：2018-04-06

申请人： Tambo, Inc. ,  The Research Foundation for The State University of New York

发明人： MEJIA ONETO, Jose Manuel ,  YEE, Nathan ,  ROYZEN, Maksim ,  SRINIVASAN, Sangeetha ,  MILLER, Ethan

IPC分类号： A61K47/54 ,  A61K47/69 ,  C07D295/185 ,  C07H5/04 ,  C07C271/24 ,  C07D295/13 ,  C07K5/062 ,  C08L5/08

公开(公告)号：EP4458896A2

公开(公告)日：2024-11-06

申请号：EP24179654.9

申请日：2018-04-06

申请人： Tambo, Inc. ,  The Research Foundation for The State University of New York

发明人： MEJIA ONETO, Jose Manuel ,  YEE, Nathan ,  ROYZEN, Maksim ,  SRINIVASAN, Sangeetha ,  MILLER, Ethan

IPC分类号： C08L5/08

摘要： Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.

公开(公告)号：EP3993834A1

公开(公告)日：2022-05-11

申请号：EP20747277.0

申请日：2020-07-06

申请人： Tambo, Inc.

发明人： MEJIA ONETO, Jose Manuel ,  YEE, Nathan A. ,  SRINIVASAN, Sangeetha ,  ZAKHARIAN, Michael

IPC分类号： A61K47/54 ,  A61K47/61 ,  A61K47/69 ,  A61P35/00 ,  C07H21/02

公开(公告)号：EP4192506A1

公开(公告)日：2023-06-14

申请号：EP21762921.1

申请日：2021-08-06

申请人： Tambo, Inc.

发明人： MEJIA ONETO, Jose Manuel ,  YEE, Nathan A. ,  SRINIVASAN, Sangeetha ,  ZAKHARIAN, Michael ,  MCFARLAND, Jesse M.

IPC分类号： A61K47/54 ,  A61P35/00