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    Arylvinylazacycloalkane compounds and methods of preparation and use thereof
    3.
    发明公开
    Arylvinylazacycloalkane compounds and methods of preparation and use thereof 有权
    Arylvinylazacycloalkan化合物和它们的制备方法和使用

    公开(公告)号：EP2085395A1

    公开(公告)日：2009-08-05

    申请号：EP09075124.9

    申请日：2004-03-04

    申请人： Targacept, Inc.

    发明人： Genevois-Borella, Arielle ,  Miller, Craig Harrison

    IPC分类号： C07D405/14 ,  A61K31/4439 ,  A61P29/00

    CPC分类号： A61K31/506 ,  C07D405/14

    摘要： The vinylazacycloalkane compound 3-(2-pyrrolidin-3-ylvinyl)-5-(tetrahydropyran-4-yloxy)pyridine is disclosed. The compound is a ligand of nAChRs. The compound and its pharmaceutically acceptable salt can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction of nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of the type of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioural disorders and inflammatory disorders within the gastrointestinal system. The compound can also serve as analgesics in the treatment of acute, chronic or recurrent pain.

    摘要翻译： 所述vinylazacycloalkane化合物3-（2-吡咯烷-3-基乙烯基）-5-（四氢吡喃-4-基氧基）吡啶是游离缺失盘。 的化合物是烟碱受体的配体。 的化合物和其药学上可接受的盐可用于制备意在预防或治疗与nAChRs的功能障碍有关的病症的药物组合物和/或药物，尤其是中枢神经系统或胃肠道系统内的爱。病症的类型的示例做了können 治疗包括神经变性疾病，包括中枢神经系统疾病：例如阿尔茨海默氏病，认知障碍，运动障碍：例如帕金森氏症，药物成瘾，行为障碍和炎性病症，胃肠系统内因此，化合物可以作为镇痛药在治疗急性 ，慢性或复发性疼痛。

    Arylvinylazacycloalkane compounds and methods of preparation and use thereof
    4.
    发明公开
    Arylvinylazacycloalkane compounds and methods of preparation and use thereof 有权
    Arylvinylazacycloalkan化合物及其制造方法和用途

    公开(公告)号：EP1947100A1

    公开(公告)日：2008-07-23

    申请号：EP08075106.8

    申请日：2004-03-04

    申请人： Targacept, Inc.

    发明人： Schmitt, Jeffrey Daniel ,  Dull, Gary Maurice ,  Genevois-Borella, Arielle ,  Capet, Marc ,  Cheve, Michel

    IPC分类号： C07D405/14 ,  A61K31/4439 ,  A61P29/00

    CPC分类号： A61K31/506 ,  C07D405/14

    摘要： Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction on nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of types of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioural disorders and inflammatory disorders within the gastrointestinal system. The compounds can also serve as analgesics in the treatment of acute, chronic or recurrent pain.

    摘要翻译： 式（I）的新颖vinylazacycloalkane化合物是游离缺失盘。 的化合物是各种nAChRs的的配位体。 的化合物和它们的药学上可接受的盐可用于制备意在预防或治疗与功能障碍上nAChRs的相关病症的药物组合物和/或药物，爱尤其是中枢神经系统或胃肠道系统内。类型障碍的实例也可以治疗 包括神经变性疾病，包括中枢神经系统疾病：例如阿尔茨海默氏病，认知障碍，运动障碍：例如帕金森氏症，药物成瘾，行为障碍和炎性病症，胃肠系统内因此这些化合物可以用作止痛剂在急性治疗， 慢性或复发性疼痛。