公开(公告)号：EP2519501B1

公开(公告)日：2015-04-22

申请号：EP10803206.1

申请日：2010-12-28

Applicant: Technische Universität Wien

Inventor： MIHOVILOVIC, Marko ,  SCHNUERCH, Michael ,  KOLEY, Moumita ,  HILBER, Karlheinz ,  KOENIG, Xaver

IPC: C07D213/74 ,  C07D239/48 ,  A61K31/44 ,  A61K31/505 ,  A61P9/00 ,  C12N5/00

CPC classification number: C07D239/48 ,  C07D213/74 ,  C12N5/0657 ,  C12N2500/40

公开(公告)号：EP2758378A1

公开(公告)日：2014-07-30

申请号：EP12781252.7

申请日：2012-09-21

Applicant: Technische Universität Wien

Inventor： MIHOVILOVIC, Marko ,  SCHNÜRCH, Michael ,  HILBER, Karlheinz ,  KÖNIG, Xaver ,  LINDER, Thomas ,  MIKE, Agnes

IPC: C07D251/02 ,  C12N5/00

CPC classification number: C12N5/0657 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C12N2501/999 ,  C12N2506/30

Abstract: The invention relates to the use of a compound of the following formula (I), for triggering the differentiation of mammalian cells from cardiomyocyte-like cells, the X being, independently, -NR
4 - or -O-, R
4 being hydrogen or C
1-6 -alkyl; R
1 being hydroxy, C
1-6 -alkyl, C
1-6 -alkoxy, carboxy, C
1-6 -alkoxycarbonyl, halogen, cyano, nitro, formyl, amino, C-i-6-alkylamino or Di-C
1-6 -alkylamino which, if necessary, are further substituted with one or more R
5 substituents selected from hydroxy, halogen, cyano and nitro; n equalling 0 to 5; R
2 being hydrogen, aryl, heteroaryl or C
1-6 -alkyl, an aryl- or heteroaryl group being further substituted, if necessary, with one or more R
6 substituents, the same options applying for R
6 as for R
1 , and one C
1-6 -alkyl group being further substituted, if necessary, with one or more R
5 substituents; R
3 being hydrogen, halogen, NR
4 R
7 , OR
7 , SR
7 or R
7 , and the same options applying for R
7 as for R
2 ; with the proviso that this compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.

公开(公告)号：EP2519501A2

公开(公告)日：2012-11-07

申请号：EP10803206.1

申请日：2010-12-28

Applicant: Technische Universität Wien ,  Medizinische Universität Wien

Inventor： MIHOVILOVIC, Marko ,  SCHNUERCH, Michael ,  KOLEY, Moumita ,  HILBER, Karlheinz ,  KOENIG, Xaver

IPC: C07D213/74 ,  C07D239/48 ,  A61K31/44 ,  A61K31/505 ,  A61P9/00 ,  C12N5/00

CPC classification number: C07D239/48 ,  C07D213/74 ,  C12N5/0657 ,  C12N2500/40

Abstract: A process for the production of cardiomocyte-like cells from mammalian cells, comprising cultering mammalian cells in the presence of a compound of formula (I) wherein the radicals have various meanings, compounds of formula (I), wherein the radicals have various meanings and the pharmaceutical use of compounds of formula (I) for the production of cardiomyocyte-like cells from omnipotent, pluripotent or lineage committed mammalian cells and the use of thus produced cardiomyocyte-like cells for treating disorders associated with impaired function of the heart.