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    Monoclonal antibodies to human plasma prekallikrein and methods of preparing and using same
    2.
    发明公开
    Monoclonal antibodies to human plasma prekallikrein and methods of preparing and using same 失效
    单克隆抗体对人体血浆前血管舒缓素及其制备方法和用途。

    公开(公告)号：EP0210029A2

    公开(公告)日：1987-01-28

    申请号：EP86305373.2

    申请日：1986-07-14

    申请人： Temple University of the Commonwealth System of Higher Education

    发明人： Veloso, Dulce C. ,  Colman, Robert W.

    IPC分类号： C07K15/00 ,  C12P21/00 ,  C12N15/00 ,  C12N5/00 ,  G01N33/573 ,  G01N33/577

    CPC分类号： C07K16/40 ,  A61K38/00

    摘要： Four novel cell lines, ATCC #HB-8862 through ATCC #HB-8865 produce monoclonal antibody to human plasma prekallikrein. At least three of the antibodies also recognize plasma kallikrein, specifically the heavy chain thereof, and kallikrein-Cl-inhibitor complex. The anti­bodies do not cross-react with tissue kallikrein. The hybridomas are formed by fusing spleen cells from immun­ized BALB/c AnSkh mice with SP2/O-Agl4 myeloma cells. Diagnostic, therapeutic and biochemical uses of the monoclonal antibodies are provided.

    摘要翻译： 四个新的细胞系，ATCC＃HB-8862通过ATCC＃HB-8865产生的单克隆抗体对人血浆激肽释放酶原。 至少三个的抗体的识别由此血浆血管舒缓素，特别是重链，以及它们的激肽释放酶 - 氯 - 抑制剂复合物。 该抗体不与组织激肽释放酶交叉反应。 该杂交瘤通过来自免疫BALB / c小鼠融合脾细胞与AnSkh SP2 / O骨髓瘤细胞Agl4形成。 提供的单克隆抗体的诊断，治疗和生化用途。