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1.发明公开
公开(公告)号：EP4050861A1
公开(公告)日：2022-08-31
申请号：EP21804205.9
申请日：2021-04-09
摘要： Disclosed in the present application are an audio signal post-processing method and device, a storage medium, and an electronic device. The method comprises: obtaining a first speech signal, performing frame splitting processing on the first speech signal, and then converting into multiple frames of first frequency domain signals, performing confusion processing on first sub-frequency domain signals less than or equal to a target frequency threshold in each frame of first frequency domain signal, and reserving second sub-frequency domain signals greater than the target frequency threshold in each frame of first frequency domain signal, and then performing frame combining processing on the obtained multiple frames of second frequency domain signals to obtain a second speech signal.
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公开(公告)号：EP4239640A1
公开(公告)日：2023-09-06
申请号：EP22745198.6
申请日：2022-01-24
发明人： YU, Yang , ZHENG, Liangzhen , LIU, Yixuan
IPC分类号： G16C20/50
摘要： A drug molecule processing method and apparatus based on artificial intelligence, and an electronic device, a computer-readable storage medium and a computer program product, which relate to artificial intelligence technology. The method comprises: determining multiple candidate drug molecules for a target protein; performing activity prediction processing on the basis of the multiple candidate drug molecules and the target protein to obtain activity information of each candidate drug molecule; performing homology modeling processing on the target protein to obtain a reference protein having a homologous structure to the target protein; performing molecular docking processing on the basis of the reference protein and the multiple candidate drug molecules to obtain molecular docking information of each candidate drug molecule; and performing screening processing on the multiple candidate drug molecules on the basis of the activity information of each candidate drug molecule and the molecular docking information of each candidate drug molecule to obtain a target drug molecule for the target protein.
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3.发明公开
公开(公告)号：EP4394781A1
公开(公告)日：2024-07-03
申请号：EP23851324.6
申请日：2023-05-26
发明人： ZHAO, Peilin , YU, Yang , LU, Chan
IPC分类号： G16C20/30
摘要： The present application relates to the technical field of backward reactions in the field of chemistry, and provides a reactant molecule prediction method and apparatus, a training method and apparatus, and an electronic device. The method comprises: extracting features of a product molecule to obtain the features of the product molecule; on the basis of the features of the product molecule, predicting a conversion path from the product molecule to a plurality of reactant molecules by using a backward reaction prediction model; and predicting synthons and completed synthons according to the conversion path to obtain the plurality of reactant molecules corresponding to the product molecule. The method provided by the present application can reduce the prediction complexity of reactant molecules, improve the generalization performance of reactant molecule prediction, and also can improve the prediction performance of the reactant molecules.
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公开(公告)号：EP4406962A1
公开(公告)日：2024-07-31
申请号：EP23834811.4
申请日：2023-07-03
IPC分类号： C07K5/027 , C07D491/20 , A61K31/407 , A61P31/14 , C07K5/097
CPC分类号： A61K31/407 , A61K38/06 , A61P31/14 , C07D487/10 , C07D491/20 , C07D498/10 , C07K5/0205 , C07K5/0821
摘要： The present disclosure provides a compound. The compound is a compound shown in formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt, or a prodrug of the compound shown in formula (I). The compound shown in formula (I) can significantly inhibit MPro or inhibit coronavirus replication, and has excellent metabolic stability.
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5.发明公开
公开(公告)号：EP4266317A1
公开(公告)日：2023-10-25
申请号：EP22766169.1
申请日：2022-02-28
发明人： XU, Tingyang , HUANG, Junhong , XU, Shaoyong , TIAN, Li , CHEN, Xinde , LIU, Wei , HUANG, Junzhou , XUE, Ding , YU, Yang
摘要： Provided are a molecular structure reconstruction method and apparatus, a device, and a readable storage medium, relating to the field of machine learning. The method includes: 101: obtaining a set of structural data of a reference molecule, the reference molecule being a molecule that is active against a pre-set target, 102: performing structural separation on the obtained set of structural data to obtain a plurality of subsets of group data each corresponding to one of a plurality of molecular segment groups of the reference molecule, 103: performing feature processing on the group data of the molecular segment group to obtain a candidate segment for replacing the fragment segment, and 104: generating structural data of a reconstructed molecule based on the candidate segment and the side chain segment.
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公开(公告)号：EP4227949A1
公开(公告)日：2023-08-16
申请号：EP22745144.0
申请日：2022-01-21
发明人： YU, Yang , LU, Chan , ZHAO, Peilin
IPC分类号： G16C20/10
摘要： Disclosed in the present application are a retrosynthesis prediction method for a compound molecule, and a related apparatus. The method comprises: obtaining a target molecule, and using the target molecule as a root node in a tree structure; then performing extension processing on a first leaf node by means of a target retrosynthesis model so as to obtain a plurality of second leaf nodes; further, performing recursive processing on a predicted molecule set corresponding to the second leaf nodes, and determining an end node that satisfies a preset condition; and further, traversing path information corresponding to the end node so as to determine a retrosynthesis path of the target molecule. Therefore, the retrosynthesis prediction process of a multi-step reaction is achieved, and using step-by-step recursive extension and screening the leaf nodes can ensure the reliability of a reactant determined by means of the retrosynthesis prediction process of the multi-step reaction, and improve the accuracy of the retrosynthesis prediction of the compound molecule.
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7.发明公开
公开(公告)号：EP4198991A1
公开(公告)日：2023-06-21
申请号：EP22766179.0
申请日：2022-02-28
发明人： XU, Tingyang , YU, Yang , RONG, Yu , LIU, Wei , HUANG, Junzhou , TU, Guiping , QIU, Yaping , CHENG, Xuemin
IPC分类号： G16B15/30
摘要： A method and an apparatus for processing molecular scaffold transitions, a computer-readable medium, an electronic device, and a computer program product are provided. The method for processing molecular scaffold transitions includes: generating, according to a connection graph structure corresponding to a reference drug molecule, an atomic latent vector corresponding to the reference drug molecule; performing atom masking processing on the atomic latent vector to obtain a scaffold latent vector and a sidechain latent vector included in the atomic latent vector; generating a target scaffold latent vector with a target transition degree between the scaffold latent vector and the target scaffold latent vector according to a spatial distribution of the scaffold latent vector; and generating a transitioned drug molecule according to the target scaffold latent vector and the sidechain latent vector.
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公开(公告)号：EP2883144A1
公开(公告)日：2015-06-17
申请号：EP13827977.3
申请日：2013-08-02
发明人： YU, Yang
IPC分类号： G06F11/36
CPC分类号： G09G5/08 , A63F13/42 , A63F13/577 , G06F3/038 , G06F3/0484 , G06F3/04842 , G06F17/30831 , H04N21/4725 , H04N21/4728
摘要： Embodiments of the present invention provide a hit testing method and apparatus. The method includes: replacing color values of pixels of objects displayed on the screen with corresponding identifier (ID) values of the objects; storing the ID values in a bitmap array, wherein each element of the bitmap array corresponds to one or more pixels of a respective object; in response to capturing a hit event, acquiring a hit coordinate on the screen corresponding to the hit event; determining a bitmap array element corresponding to the hit coordinate; and identifying an object related to the hit event, according to the ID value associated with the bitmap array element.
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