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公开(公告)号：EP3391930A1
公开(公告)日：2018-10-24
申请号：EP17770318.8
申请日：2017-03-23
发明人： KUROSAKI, Yasuo , MORIMOTO, Katsumi , MURATA, Yu , GOTO, Hiroshi
IPC分类号： A61M25/10 , A61K31/337 , A61K31/436 , A61L29/12 , A61L29/16 , A61P9/00
CPC分类号： A61M25/10 , A61K31/337 , A61K31/436 , A61L29/16 , A61M25/0026 , A61M25/1029 , A61M25/104 , A61M2025/0039 , A61M2025/1031 , A61M2025/105 , A61M2025/1061 , A61M2025/1075 , A61M2025/1086 , B05D1/002 , B05D1/26 , B05D1/42 , B05D2401/20 , C30B7/06 , C30B29/58 , C30B29/62
摘要： There are provided a balloon catheter by which a drug can be effectively delivered to living body tissue and the deliverability can be controlled and a manufacturing method thereof, and a treatment method. Disclosed is a balloon catheter (10) provided on an outer surface of a balloon (30) with a plurality of elongate bodies (42) which are crystals of a water-insoluble drug extending while having independent long axes. The balloon catheter (10) has a base layer (41) including a water-soluble low-molecular compound disposed in a layer form on the outer surface of the balloon (30), and at least part of the elongate bodies (42) is located in the inside of the base layer (41).
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公开(公告)号：EP3338850A1
公开(公告)日：2018-06-27
申请号：EP16848666.0
申请日：2016-09-23
发明人： KUROSAKI, Yasuo , GOTO, Hiroshi
IPC分类号： A61M25/10
CPC分类号： B29C53/08 , A61M25/1029 , A61M25/1038 , B29C33/76 , B29C51/10 , B29C53/566 , B29C53/825 , B29C70/682 , B29L2031/7543
摘要： Provided is a balloon wrapping apparatus and a balloon wrapping method by which a balloon can be wrapped appropriately.
The balloon wrapping apparatus for wrapping a balloon (52) of a balloon catheter (50) provided with the balloon (52) at a distal portion of an elongated shaft (51) includes: a pleating section (2) that forms the balloon (52) with wing shapes projecting in radial directions; a folding section (3) that includes a plurality of blades (22) aligned in a circumferential direction, and that folds the wing shapes formed in the balloon (52) along the circumferential direction by moving rotationally the blades (22); and a rotational support portion (33) that supports a portion of the shaft (51) which portion is on a proximal side of the balloon (52), and that rotates the shaft (51) in a direction opposite to a rotary movement direction of the blades (22) in a state in which the balloon (52) is positioned in relation to the folding section (3).-
公开(公告)号：EP3338849A1
公开(公告)日：2018-06-27
申请号：EP16848665.2
申请日：2016-09-23
发明人： KUROSAKI, Yasuo , GOTO, Hiroshi
IPC分类号： A61M25/10
CPC分类号： A61M25/1038 , A61M25/10 , A61M2025/105 , B29C51/10 , B29C53/08 , B29C53/566 , B29C53/825 , B29C70/682 , B29L2031/7543
摘要： Provided are a balloon wrapping apparatus and a balloon wrapping method by which a balloon can be accurately positioned in relation to a pleating section and to a folding section.
The balloon wrapping apparatus for wrapping a balloon (52) of a balloon catheter (50) provided with the balloon (52) at a distal portion of an elongated shaft (51) includes: a pleating section (2) that has a plurality of blades (12) aligned with space parts therebetween in a circumferential direction, and that forms the balloon (52) with wing shapes projecting in radial directions by clamping the balloon (52) in the space parts by moving rotationally the blades (12); a folding section (3) that has a plurality of blades (22) aligned in a circumferential direction, and that folds the wing shapes formed in the balloon (52) in the circumferential direction by moving rotationally the blades (22); a support base (4) that supports a part of the shaft (51) which part is on a proximal side of the balloon (52); and a grasping section (110) capable of grasping a part of the balloon catheter (50) which part is on a distal side of the balloon (52).-
公开(公告)号：EP3064247B1
公开(公告)日：2018-06-27
申请号：EP14871255.7
申请日：2014-12-19
发明人： KUROSAKI, Yasuo , FURUICHI, Eisuke , GOTO, Hiroshi
IPC分类号： A61M25/10 , B05C5/02 , B05C11/10 , B05C13/02 , B05D1/40 , B05D7/00 , A61L29/16 , A61L29/08 , B05D1/00 , A61K31/337 , B05D1/26 , B05D3/00
CPC分类号： B05D3/007 , A61K31/337 , A61L29/08 , A61L29/16 , A61L2300/416 , A61L2420/02 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2207/10 , B05C5/02 , B05C11/1005 , B05C13/025 , B05D1/002 , B05D1/26
摘要： [Obj ect] Provided are a balloon coating method and a balloon coating apparatus by which the thickness and/or morphological form of a drug in a coating formed on a balloon can be appropriately set. [Solution] The balloon coating method and the balloon coating apparatus (50) are for forming a coating layer (32) on a surface of a balloon (30). The balloon coating method includes: a coating step of moving a coating section (94) for applying a coating liquid (R) containing a drug relative to the balloon (30) in the direction of an axis (X), while rotating the balloon (30) about the axis (X) of the balloon (30), thereby to apply the coating liquid (R) to an outer surface of the balloon (30); a detection step of detecting the distance (L) of a dried part (B) where the coating liquid (R) applied to the outer surface of the balloon (30) has been dried from the coating section (94); and a control step of controlling moving velocity (Sx) of the coating section (94) relative to the balloon (30) in such a manner that the distance (L) of the dried part (B) from the coating section (94) is maintained at a preliminarily set designated distance (L0).
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公开(公告)号：EP3064247A1
公开(公告)日：2016-09-07
申请号：EP14871255.7
申请日：2014-12-19
发明人： KUROSAKI, Yasuo , FURUICHI, Eisuke , GOTO, Hiroshi
CPC分类号： B05D3/007 , A61K31/337 , A61L29/08 , A61L29/16 , A61L2300/416 , A61L2420/02 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2207/10 , B05C5/02 , B05C11/1005 , B05C13/025 , B05D1/002 , B05D1/26
摘要： [Obj ect]
Provided are a balloon coating method and a balloon coating apparatus by which the thickness and/or morphological form of a drug in a coating formed on a balloon can be appropriately set.
[Solution]
The balloon coating method and the balloon coating apparatus (50) are for forming a coating layer (32) on a surface of a balloon (30). The balloon coating method includes: a coating step of moving a coating section (94) for applying a coating liquid (R) containing a drug relative to the balloon (30) in the direction of an axis (X), while rotating the balloon (30) about the axis (X) of the balloon (30), thereby to apply the coating liquid (R) to an outer surface of the balloon (30); a detection step of detecting the distance (L) of a dried part (B) where the coating liquid (R) applied to the outer surface of the balloon (30) has been dried from the coating section (94); and a control step of controlling moving velocity (Sx) of the coating section (94) relative to the balloon (30) in such a manner that the distance (L) of the dried part (B) from the coating section (94) is maintained at a preliminarily set designated distance (L0).摘要翻译： 其目的在于提供一种能够适当地设定在气球上形成的涂膜中的药剂的厚度和/或形态的气囊涂布方法及气囊涂布装置。 [解决方案]球囊涂布方法和球囊涂布装置（50）用于在球囊（30）的表面上形成涂布层（32）。 该球囊涂布方法包括：涂布步骤，在旋转球囊（30）的同时沿轴（X）的方向移动用于涂布含有药物的涂布液（R）的涂布部分（94） （30）的轴线（X），从而将涂布液（R）施加到球囊（30）的外表面; 检测步骤，检测从所述涂布部分（94）涂布到所述球囊（30）的外表面的涂布液（R）已经干燥的干燥部分（B）的距离（L）; 以及控制步骤，控制涂覆部分（94）相对于球囊（30）的移动速度（Sx），使得干燥部分（B）距涂覆部分（94）的距离（L）为 保持在预先设定的指定距离（L0）。
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6.发明公开
公开(公告)号：EP2684551A1
公开(公告)日：2014-01-15
申请号：EP12755195.0
申请日：2012-01-20
发明人： ISHIZUKA, Takanobu , TOKUE, Shinichi , KASUKAWA, Hiroaki , KANEDA, Shinichi , GOTO, Hiroshi , KUROSAKI, Yasuo , MORIMOTO, Katsumi
IPC分类号： A61J1/10
CPC分类号： A61J1/10 , A61J1/2034 , A61J1/2093 , A61M1/32 , A61M5/14232 , A61M2202/0208 , A61M2202/0476 , A61M2210/0693
摘要： To provide a system for delivering an oxygen carrier, whereby a deoxygenated oxygen carrier can be oxygenated and efficiently delivered to an ischemic tissue, an oxygenation device for an oxygen carrier, and a housing for an oxygen carrier. A system (10) for delivering an oxygen carrier, the system including: a housing (2) in which a hemoglobin-based oxygen carrier is housed in a deoxygenated state; an oxygenation part for oxygenating the deoxygenated oxygen carrier; and a long element (5) which can be inserted into a living organism and can release the oxygenated oxygen carrier through a lumen (52) that is formed inside thereof.
摘要翻译： 以提供用于在氧载体输送氧气，以载体，由此脱氧氧载体可以氧化和有效地传递向缺血组织，在氧合装置的系统，以及用于在氧载体的壳体。 一种用于输送氧气载体系统（10），所述系统包括：外壳（2），其中基于血红蛋白的氧载体在无氧状态一栋; 氧合一部分充氧脱氧氧载体; 并且其可以被插入到生物体中，并可以通过一个管腔（52）释放所述含氧的载氧体做了长元件（5）在其内部形成。
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公开(公告)号：EP3406293A1
公开(公告)日：2018-11-28
申请号：EP17770320.4
申请日：2017-03-23
IPC分类号： A61M25/10 , A61K31/337 , A61K31/436 , A61L29/16 , A61P9/00
CPC分类号： A61K31/337 , A61K31/436 , A61L29/16 , A61M25/10
摘要： Provided are a balloon catheter that can effectively deliver a drug to living body tissue and a manufacturing method thereof, and a treatment method. A balloon catheter 10 has a balloon 12 at a distal portion of a catheter shaft 11, and is provided on a surface of the balloon 12 with a plurality of elongate bodies 33 which are crystals of a water-insoluble drug extending while having independent long axes. The balloon 12 in a deflated state has a plurality of wing portions 40 in a circumferential direction, and a circumferential surface portion 41 along a circumferential direction of the catheter shaft 11, the wing portions 40 being folded along the circumferential direction of the balloon 12. That surface of the circumferential surface portion 41 which faces the folded wing portion 40 has a region in which tip portions of the elongate bodies 33 are not in contact with the surface of the balloon 12 or with other elongate bodies 33. That surface of the folded wing portion 40 which faces an outer circumferential side has a region in which the tip portions of the elongate bodies 33 are in contact with the surface of the balloon 12 or with other elongate bodies 33.
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公开(公告)号：EP3391933A1
公开(公告)日：2018-10-24
申请号：EP18172701.7
申请日：2014-12-19
发明人： GOTO, Hiroshi , FURUICHI, Eisuke , KUROSAKI, Yasuo
摘要： Provided is a balloon coating method and apparatus which can perform coating while freely controlling, for example, the thickness of a coating layer and/or the morphological form of a drug.
The balloon coating method and the balloon coating apparatus (50) are for forming a coating layer (32) on a surface of a balloon (30). The balloon coating method includes: a pulling step of pulling the balloon (30) in the direction of an axis (X) of the balloon (30) to thereby straighten a bend of the balloon (30); and a coating step of rotating the balloon (30) about the axis (X) of the balloon (30), with the balloon (30) maintained in the bend-straightened state, and coating an outer surface of the balloon (30) with a coating liquid (R) containing a drug.-
公开(公告)号：EP3338851A1
公开(公告)日：2018-06-27
申请号：EP16848667.8
申请日：2016-09-23
发明人： KUROSAKI, Yasuo , GOTO, Hiroshi
IPC分类号： A61M25/10
CPC分类号： B29C53/08 , A61M25/10 , A61M25/1034 , A61M25/1038 , A61M2025/105 , B29C33/76 , B29C51/10 , B29C53/566 , B29C53/821 , B29C70/682 , B29L2031/7543
摘要： Provided is a balloon wrapping apparatus by which a balloon can be accurately positioned and inserted in relation to a pleating section. The balloon wrapping apparatus for wrapping a balloon 52 provided at a distal portion of an elongated shaft 51 includes: a pleating section 2 that forms the balloon 52 with wing shapes; a folding section 3 that folds the wing shapes formed in the balloon 52 along a circumferential direction; a support base 4 that supports a portion other than the distal portion of the shaft 51, and that makes the distal portion of the shaft 51 insertable into the pleating section 2 and the folding section 3; and a core metal member 6 to be inserted in the shaft 51. The core metal member 6 is inserted in the shaft 51 from a distal end position of the balloon 52 to at least the proximal side of a proximal end position of the balloon 52.
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公开(公告)号：EP3106197A1
公开(公告)日：2016-12-21
申请号：EP15772734.8
申请日：2015-03-20
发明人： KUROSAKI, Yasuo , GOTO, Hiroshi , FURUICHI, Eisuke
CPC分类号： B05D1/26 , A61L29/08 , A61L29/16 , A61L2300/416 , A61L2420/02 , A61M25/10 , A61M25/1029 , A61M2025/1031 , B05B13/0442 , B05C5/02 , B05C5/0208 , B05C5/0216 , B05C13/025 , B05D1/002 , B05D7/04
摘要： A balloon coating method which makes it possible to suitably set the thickness and morphological form of a drug in a coating formed on a balloon is provided. The balloon coating method is for forming a coating layer (32) containing a water-insoluble drug on an outer surface of a balloon (30) of a balloon catheter (10). The balloon coating method includes an application step in which, where a flexible dispensing tube (94) for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion (95) for discharging the coating solution therethrough and when the opening portion-formed end portion side of the dispensing tube (94) is kept in contact with the outer surface of the balloon (30) in such a manner as to be oriented in a direction opposite to a rotating direction of the balloon (30) while the balloon (30) is rotated about an axis of the balloon (30), the coating solution is discharged through the opening portion (95) and applied to the outer surface of the balloon (30) while the dispensing tube (94) is moved relative to the balloon (30) in an axial direction X of the balloon (30).
摘要翻译： 提供了一种气球涂覆方法，其可以适当地设定在气囊上形成的涂层中的药物的厚度和形态形式。 气球涂布法是在气囊导管（10）的球囊（30）的外表面上形成含有水不溶性药物的被覆层（32）。 球囊涂布方法包括如下步骤：其中，在其端部形成用于供给含有不溶于水的药物和溶剂的涂布液的柔性分注管（94），其具有用于排出涂层的开口部（95） 并且当所述分配管（94）的开口部形成端部侧与所述气球（30）的外表面保持接触时，使其沿与所述气囊（30）的旋转方向相反的方向定向 气囊（30）围绕球囊（30）的轴线旋转时，涂覆液通过开口部分（95）排出并施加到球囊（30）的外表面，同时分配 管（94）相对于球囊（30）在气球（30）的轴向方向X上移动。
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