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公开(公告)号：EP2459176A2
公开(公告)日：2012-06-06
申请号：EP10805109.5
申请日：2010-07-30
发明人： HANNA, Mazen , SHAN, Ning , CHENEY, Miranda , WEYNA, David , HOUCK, Raymond, K.
CPC分类号： C07F9/65061 , A61K31/375 , C07B2200/13 , C07F9/6506
摘要： Preparation, in -vitro and in vivo characterization of novel forms of ( 1 -hydroxy- 2-imida/ol-l-yl-l -phosphono-cthyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
摘要翻译： 新颖形式的（1-羟基-2-咪唑啉-1-基-1-膦酰基 - 乙基）膦酸的制备，体内和体内表征，适用于人用药物递送系统中的药物组合物。
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2.发明公开A METHOD FOR INCREASING THE AQUEOUS SOLUBILITY OF A BISPHOSPHONIC ACID OR A BISPHOSPHONATE 审中-公开用于增加WASSERLÖSSLICHKEIT一个BIPSHOPSHONSÄURE或双膦酸盐的一种方法
公开(公告)号：EP3158867A1
公开(公告)日：2017-04-26
申请号：EP16187412.8
申请日：2010-07-30
发明人： HANNA, Mazen , SHAN, Ning , CHENEY, Miranda , WEYNA, David
IPC分类号： A01N57/00 , A61K31/675 , C07F9/6506
CPC分类号： A61K31/675 , A61K31/401 , A61K31/4172 , C07F9/6506
摘要： Novel solution complexes of zoledronic acid are described which give rise to improved properties of zoledronic acid. The invention includes aqueous solution and molecular complexes of zoledronic acid with and optical isomers of asparagine, histidine, arginine and proline as well as pharmaceutical complexes containing them and methods of treatment using them.
摘要翻译： 唑来膦酸的新的解决方案的复合物描述了产生改进的唑来膦酸的性质。 本发明包括wässrige溶液和唑来膦酸的分子复合物和天冬酰胺，组氨酸，精氨酸和脯氨酸的光学异构体以及含有它们和使用它们的治疗方法的药物复合物。
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公开(公告)号：EP2458996B1
公开(公告)日：2016-09-07
申请号：EP10805114.5
申请日：2010-07-30
发明人： HANNA, Mazen , SHAN, Ning , CHENEY, Miranda , WEYNA, David
IPC分类号： A01N57/00 , A61K31/675 , C07F9/6506
CPC分类号： A61K31/675 , A61K31/401 , A61K31/4172 , C07F9/65061
摘要： Novel solution complexes of zoledronic acid are described which give rise to improved properties of zoledronic acid. The invention includes aqueous solution and molecular complexes of zoledronic acid with and optical isomers of asparagine, histidine, arginine and proline as well as pharmaceutical complexes containing them and methods of treatment using them.
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公开(公告)号：EP2458996A1
公开(公告)日：2012-06-06
申请号：EP10805114.5
申请日：2010-07-30
发明人： HANNA, Mazen , SHAN, Ning , CHENEY, Miranda , WEYNA, David
IPC分类号： A01N57/00 , A61K31/675 , C07F9/06
CPC分类号： A61K31/675 , A61K31/401 , A61K31/4172 , C07F9/65061
摘要： Novel solution complexes of zoledronic acid are described which give rise to improved properties of zoledronic acid. The invention includes aqueous solution and molecular complexes of zoledronic acid with and optical isomers of asparagine, histidine, arginine and proline as well as pharmaceutical complexes containing them and methods of treatment using them.
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