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    ACETAMINOPHEN PROTEIN ADDUCTS AND METHODS OF USE THEREOF
    1.
    发明公开
    ACETAMINOPHEN PROTEIN ADDUCTS AND METHODS OF USE THEREOF 审中-公开
    乙酰氨基酚蛋白加合物及其使用方法

    公开(公告)号：EP3104849A1

    公开(公告)日：2016-12-21

    申请号：EP15748750.5

    申请日：2015-02-13

    申请人： The Board of Trustees of the University of Arkansas ,  Arkansas Children's Hospital Research Institute, Inc.

    发明人： JAMES, Laura P. ,  HINSON, Jack ,  ROBERTS, Dean ,  GILL, Pritmohinder S.

    IPC分类号： A61K31/167

    CPC分类号： C12Q1/48 ,  C07K14/4708 ,  C12N9/1007 ,  C12N9/1014 ,  C12N9/107 ,  C12N9/1096 ,  C12Q1/527 ,  C12Y201/01005 ,  G01N33/53

    摘要： The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP-protein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine S-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin.

    摘要翻译： 本公开涉及对乙酰氨基酚蛋白加合物和使用对乙酰氨基酚蛋白加合物诊断对乙酰氨基酚毒性的方法。 本公开提供使用APAP-蛋白质加合物的对象中对乙酰氨基酚（APAP） - 蛋白质加合物和检测对乙酰氨基酚诱导的毒性的方法。 本公开的一个方面提供了用于诊断对乙酰氨基酚诱导的毒性的APAP-促胰岛素加合物。 根据本公开内容，发明人已经鉴定了在具有对乙酰氨基酚诱导毒性的受试者中被N-乙酰基 - 苯醌亚胺（NAPQI）修饰的蛋白质。 NAPQI修饰的蛋白质的非限制性例子包括甜菜碱 - 高半胱氨酸S-甲基转移酶1，细胞质天冬氨酸转氨酶，1,4-α-葡聚糖分支酶，亚胺酰基转移酶 - 环化脱氨酶和肌营养不良蛋白。