公开(公告)号：EP2763532A1

公开(公告)日：2014-08-13

申请号：EP12838386.6

申请日：2012-10-05

申请人： The Board of Trustees of the Leland Stanford Junior University ,  The Regents of The University of California

发明人： CHOONG, Ingrid ,  GLENN, Jeffrey S. ,  GELMAN, Michael A. ,  TAVSHANJIAN, Brandon ,  SHOKAT, Kevan

IPC分类号： A01N43/00

CPC分类号： C07D417/12 ,  C07D277/40 ,  C07D277/42 ,  C07D277/44 ,  C07D277/46

摘要： Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.

公开(公告)号：EP2763532B1

公开(公告)日：2018-09-19

申请号：EP12838386.6

申请日：2012-10-05

申请人： The Board of Trustees of the Leland Stanford Junior University ,  The Regents of the University of California

发明人： CHOONG, Ingrid ,  GLENN, Jeffrey S. ,  GELMAN, Michael A. ,  TAVSHANJIAN, Brandon ,  SHOKAT, Kevan

IPC分类号： C07D277/44 ,  C07D417/12 ,  C07D277/40 ,  C07D277/46 ,  C07D277/42

CPC分类号： C07D417/12 ,  C07D277/40 ,  C07D277/42 ,  C07D277/44 ,  C07D277/46

摘要： Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.

公开(公告)号：EP3419980A1

公开(公告)日：2019-01-02

申请号：EP17757378.9

申请日：2017-02-24

申请人： The Board of Trustees of the Leland Stanford Junior University ,  The Regents of the University of California

发明人： GLENN, Jeffrey S. ,  GELMAN, Michael A. ,  TAVSHANJIAN, Brandon ,  SHOKAT, Kevan ,  CHOONG, Ingrid ,  SMITH, Mark

IPC分类号： C07D498/04 ,  C07D419/04