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    Use of gene expression profiling to predict survival in cancer patient
    1.
    发明公开
    Use of gene expression profiling to predict survival in cancer patient 有权
    Verwendung von Genexpressionsprofilen zur Prognose derÜberlebensratebei Krebspatienten

    公开(公告)号：EP2537942A1

    公开(公告)日：2012-12-26

    申请号：EP12150351.0

    申请日：2005-05-20

    申请人： The Board of Trustees of the University of Arkansas System

    发明人： Shaughnessy, John ,  Zhan, Fenghuang ,  Barlogie, Bart

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158

    摘要： Gene expression profiling in multiple myeloma patients identifies genes that distinguish between patients with subsequent early death or long survival after treatment. Poor survival is linked to over-expression of genes such as ASPM, OPN3 and CKS1B which are located in chromosome 1 q. Given the frequent amplification of 1 q in many cancers, it is possible that these genes can be used as powerful prognostic markers and therapeutic targets for multiple myeloma and other cancer.

    摘要翻译： 在多发性骨髓瘤患者中进行基因表达谱鉴定鉴定了随后早期死亡或治疗后长期存活的患者之间的基因。 差的存活与位于染色体1q的基因如ASPM，OPN3和CKS1B的过表达有关。 鉴于许多癌症中1q的频繁扩增，这些基因可能被用作多种骨髓瘤和其他癌症的强大的预后标志物和治疗靶点。