公开(公告)号：EP2598881A2

公开(公告)日：2013-06-05

申请号：EP11813253.9

申请日：2011-07-29

申请人： The Board of Trustees of the University of Illinois

发明人： DUDLEY, Samuel ,  NEGI, Smita

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N33/6896 ,  G01N2333/4737 ,  G01N2800/2871 ,  G01N2800/52 ,  G01N2800/7009

摘要： The invention provides methods of determining risk for stroke in a patient, as well as methods of determining a subject's need for anti-coagulation therapy. In exemplary embodiments, the method comprises measuring a level of derivatives of reactive oxygen metabolites (DROMs) in a biological sample obtained from the subject, wherein an increased level of DROMs, relative to a control level, is indicative of the subject's need for anticoagulation therapy. Further provided are methods of decreasing risk of stroke in a subject, methods of determining the efficacy of a therapeutic agent, methods of monitoring a subject's risk of stroke, and kits.