专利检索 ap:("The Brigham AND Women's Hospital, Inc." OR "Dana Farber Cancer Institute, Inc.") AND inv:"MONNEY, Laurent" 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS RELATED TO TIM-3, A TH1-SPECIFIC CELL SURFACE MOLECULE 审中-公开
标题翻译：组合物和方法中涉及TIM-3，A TH1特定的细胞表面分子

公开(公告)号：EP1467759A2

公开(公告)日：2004-10-20

申请号：EP03723627.0

申请日：2003-01-30

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , DANA-FARBER CANCER INSTITUTE, INC.

发明人： KUCHROO, Vijay, K. , MONNEY, Laurent , GREEFIELD, Edward, A. , GAGLIA, Jason, L. , FREEMAN, Gordon, J. , WALDNER, Hanspeter

IPC分类号： A61K39/395 , C07K16/28

CPC分类号： A61K39/3955 , A61K9/0019 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/34 , C07K2317/50

摘要： The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.

2.

发明公开
A TIM-3 BINDING MOLECULE FOR USE IN THE TREATMENT OF A DISEASE 审中-公开

公开(公告)号：EP4091631A1

公开(公告)日：2022-11-23

申请号：EP21197088.4

申请日：2003-01-30

申请人： The Brigham and Women's Hospital, Inc. , Dana Farber Cancer Institute, Inc.

发明人： KUCHROO, Vijay K. , MONNEY, Laurent , GREENFIELD, Edward , GAGLIA, Jason , FREEMAN, Gordon , WALDNER, Hanspeter

IPC分类号： A61K39/395 , C07K16/28

摘要： The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Thl cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.