公开(公告)号：EP2712655B1

公开(公告)日：2019-12-18

申请号：EP13194971.1

申请日：2012-04-30

申请人： The Broad Institute, Inc. ,  The General Hospital Corporation d/b/a Massachusetts General Hospital ,  Massachusetts Institute of Technology (MIT)

发明人： Holson, Edward ,  WAGNER, Florence Fevrier ,  WEIWER, Michel ,  Tsai, Li-Huei ,  HAGGARTY, Stephen J. ,  Zhang, Yan-Ling

IPC分类号： A61P35/00 ,  A61K31/38 ,  A61K31/4523 ,  A61K31/445 ,  A61K31/351 ,  A61K31/167

公开(公告)号：EP2712655A1

公开(公告)日：2014-04-02

申请号：EP13194971.1

申请日：2012-04-30

申请人： The Broad Institute, Inc. ,  The General Hospital Corporation d/b/a Massachusetts General Hospital ,  Massachusetts Institute of Technology (MIT)

发明人： Holson, Edward ,  Wagner, Florence, Février ,  Weiwer, Michel ,  Tsai, Li-Huei ,  Haggarty, Stephen ,  Zhang, Yan-Ling

IPC分类号： A61P35/00 ,  A61K31/38 ,  A61K31/4523 ,  A61K31/445 ,  A61K31/351 ,  A61K31/167

摘要： The present invention relates to compounds of formula (I):

or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R 2a , R 2b , R 2c , R 5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，水合物，溶剂合物或前药，其中U，J，V，X，R 2a，R 2b，R 2c，R 5和t为 在此描述。 本发明一般涉及组蛋白脱乙酰酶的抑制剂及其制备和使用方法。 这些化合物可用于促进认知功能和增强学习和记忆形成。 此外，这些化合物可用于治疗，减轻和/或预防各种病症，包括例如神经障碍，记忆和认知功能障碍/损伤，灭绝学习障碍，真菌疾病和感染，炎性疾病，血液疾病和 人类和动物中的肿瘤疾病。