专利检索 ap:("The Broad Institute Inc." OR "Dana-Farber Cancer Institute Inc. et Al.") AND inv:"THOMAS, David, K." 第 1 页

1.

发明公开
ANTIBODIES, COMPOUNDS AND SCREENS FOR IDENTIFYING AND TREATING CACHEXIA OR PRE-CACHEXIA 审中-公开
标题翻译：鉴定和治疗CACHEXIA或PRE-CACHEXIA的抗体，化合物和屏幕

公开(公告)号：EP3307781A1

公开(公告)日：2018-04-18

申请号：EP16733251.9

申请日：2016-06-10

申请人： The Broad Institute Inc. , Dana-Farber Cancer Institute Inc. et Al.

发明人： THOMAS, David, K. , GOLUB, Todd, R.

IPC分类号： C07K16/28 , C07D233/64 , C07C233/65 , G01N33/68 , G01N33/50 , A61K31/00

摘要： The invention provides therapeutic, engineered protein/peptide compositions comprising e.g., RAGE antibodies, T-cell receptors to target a RAGE receptor (including soluble forms thereof) directly and/or via differential competition with one or more pre-cachexia and/or cachexia-associated RAGE ligands or markers.

2.

发明授权
ANTIBODIES, COMPOUNDS AND SCREENS FOR IDENTIFYING AND TREATING CACHEXIA OR PRE-CACHEXIA 有权

公开(公告)号：EP3307781B1

公开(公告)日：2020-10-28

申请号：EP16733251.9

申请日：2016-06-10

申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute Inc. et Al.

发明人： THOMAS, David, K. , GOLUB, Todd, R.

IPC分类号： A61K31/166 , A61K31/426 , A61P43/00 , C07K16/28 , G01N33/68

3.

发明授权
ANTIBODIES, COMPOUNDS AND SCREENS FOR IDENTIFYING AND TREATING CACHEXIA OR PRE-CACHEXIA 有权

公开(公告)号：EP3307781B8

公开(公告)日：2020-12-02

申请号：EP16733251.9

申请日：2016-06-10

申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.

发明人： THOMAS, David, K. , GOLUB, Todd, R.

IPC分类号： A61K31/166 , A61K31/426 , A61P43/00 , C07K16/28 , G01N33/68