公开(公告)号：EP4462282A1

公开(公告)日：2024-11-13

申请号：EP24175192.4

申请日：2024-05-10

申请人： The Broad Institute Inc. ,  Massachusetts Institute Of Technology

发明人： CAICEDO RUEDA, Juan C. ,  QUACH, Alex ,  FONNEGRA, Ruben ,  VALI SANIAN, Mohammad ,  PAAVOLAINEN, Lassi ,  CHEN, Zitong

IPC分类号： G06F16/55 ,  G06F16/906 ,  G06N3/00

摘要： Decoupled encoder-decoder networks for image simulation and modification are described. An encoder network outputs feature representations of an input image of a biological sample, and a manipulation engine modifies the feature representations output by the encoder network by applying a variable associated with an experimental condition. A decoder network receives the modified feature representations from the manipulation engine and generates a simulated image by decoding the modified feature representations. The simulated image is a modified version of the input image that includes an estimated outcome of the experimental condition on the biological sample. The encoder network is trained separately from the decoder network, and the decoder network is adapted to the encoder network via at least one loss that is dependent on an output of the encoder network.