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1.发明授权IN VITRO AND IN VIVO DELIVERY OF GENES AND PROTEINS USING THE BACTERIOPHAGE T4 DNA PACKAGING MACHINE 有权使用噬菌体T4 DNA包装机进行基因和蛋白质的体内和体内递送
公开(公告)号：EP2964770B1
公开(公告)日：2017-06-14
申请号：EP14760017.5
申请日：2014-01-31
发明人： RAO, Venigalla
CPC分类号： C12N15/87 , C07K2319/10 , C07K2319/40 , C07K2319/61 , C12N2795/10122 , C12N2795/10123 , C12N2795/10142 , C12N2810/6009 , C12N2810/85 , C12N2810/859
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公开(公告)号：EP2542681B1
公开(公告)日：2019-02-27
申请号：EP11765160.4
申请日：2011-04-08
发明人： RAO, Venigalla
IPC分类号： C12N15/63 , C12N7/01 , A61K31/7088 , A61K31/00 , A61K39/00 , A61K31/711 , C07K14/005
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3.发明公开IN VITRO AND IN VIVO DELIVERY OF GENES AND PROTEINS USING THE BACTERIOPHAGE T4 DNA PACKAGING MACHINE 有权在体外和基因和蛋白质BY噬菌体T4 DNA封装机体内释放
公开(公告)号：EP2964770A1
公开(公告)日：2016-01-13
申请号：EP14760017.5
申请日：2014-01-31
发明人： RAO, Venigalla
CPC分类号： C12N15/87 , C07K2319/10 , C07K2319/40 , C07K2319/61 , C12N2795/10122 , C12N2795/10123 , C12N2795/10142 , C12N2810/6009 , C12N2810/85 , C12N2810/859
摘要： Described is T4 DNA packaging machine comprising: one or more DNA molecules packaged in a head of the T4 DNA packaging machine, one or more Hoc-fused proteins displayed on the head of the T4 DNA packaging machine, and one or more Soc-fused proteins displayed on the head of the T4 DNA packaging machine. Also described are methods of making and using such a T4 DNA packaging machine.
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4.发明公开PROTEIN AND NUCLEIC ACID DELIVERY VEHICLES, COMPONENTS AND MECHANISMS THEREOF 审中-公开手段蛋白质和核酸供应及其部件和机制，
公开(公告)号：EP2542681A2
公开(公告)日：2013-01-09
申请号：EP11765160.4
申请日：2011-04-08
发明人： RAO, Venigalla
CPC分类号： C12N15/86 , A61K31/7088 , A61K31/711 , A61K47/6901 , A61K48/00 , C07K14/005 , C12N7/00 , C12N15/87 , C12N15/88 , C12N2795/10042 , C12N2795/10122 , C12N2795/10142 , C12N2795/10152
摘要： Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.
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公开(公告)号：EP2129776A1
公开(公告)日：2009-12-09
申请号：EP08731065.2
申请日：2008-02-29
发明人： ALVING, Carl R. , RAO, Venigalla
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/385 , A61K2039/55555 , A61K2039/55572 , A61K2039/6075 , C07K14/005 , C07K2319/735 , C12N2740/16122 , C12N2740/16134 , C12N2795/10122
摘要： T4 bacteriophages are bound to substrates such as liposomes using a binder.
摘要翻译： 配体 - 受体粘合剂体系也可以用作T4-脂质体粘合剂。
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