公开(公告)号：EP2991488A2

公开(公告)日：2016-03-09

申请号：EP14791128.3

申请日：2014-04-30

申请人： The Chancellor, Masters and Scholars of The University of Oxford ,  Unither Virology, LLC

发明人： LAING, Peter ,  DWEK, Raymond A. ,  POLLOCK, Stephanie ,  ZITZMANN, Nicole ,  BUTTERS, Terry ,  ALONZI, Dominic ,  KIAPPES, John ,  RAMSTEDT, Urban

IPC分类号： A01N43/40 ,  A61K31/45 ,  A61K31/445

CPC分类号： C07D211/46 ,  A61K31/445 ,  A61K31/45 ,  A61K31/453

摘要： The application provides iminosugars with a high activity and specificity for inhibiting ceramide glucosyltransferase.

公开(公告)号：EP2473482B1

公开(公告)日：2014-03-05

申请号：EP10814409.8

申请日：2010-09-01

申请人： United Therapeutics Corporation ,  THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

发明人： RAMSTEDT, Urban ,  KLOSE, Brennan ,  ZITZMANN, Nicole ,  DWEK, Raymond, A. ,  BUTTERS, Terry, D.

IPC分类号： A61K31/445 ,  C07D211/30 ,  A61P31/16

CPC分类号： A61K31/445 ,  A61K31/655 ,  C07D211/46

公开(公告)号：EP2440205B1

公开(公告)日：2014-08-27

申请号：EP10786885.3

申请日：2010-06-11

申请人： United Therapeutics Corporation ,  THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

发明人： RAMSTEDT, Urban ,  KLOSE, Brennan ,  ZITZMANN, Nicole ,  DWEK, Raymond, A. ,  BUTTERS, Terry, D.

IPC分类号： A61K31/445 ,  A01N43/40 ,  A61P31/12

CPC分类号： A61K31/445 ,  Y02A50/382 ,  Y02A50/397 ,  Y02A50/409

摘要： Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives.

公开(公告)号：EP2473493A1

公开(公告)日：2012-07-11

申请号：EP10814414.8

申请日：2010-09-01

申请人： United Therapeutics Corporation ,  THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

发明人： RAMSTEDT, Urban ,  KLOSE, Brennan ,  ZITZMANN, Nicole ,  DWEK, Raymond, A. ,  BUTTERS, Terry, D.

IPC分类号： C07D307/48

CPC分类号： A61K31/445 ,  A61K31/452 ,  C07D211/46

摘要： Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Poxviridae family using iminosugars, such as DNJ derivatives.

公开(公告)号：EP2440205A1

公开(公告)日：2012-04-18

申请号：EP10786885.3

申请日：2010-06-11

申请人： United Therapeutics Corporation ,  THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

发明人： RAMSTEDT, Urban ,  KLOSE, Brennan ,  ZITZMANN, Nicole ,  DWEK, Raymond, A. ,  BUTTERS, Terry, D.

IPC分类号： A61K31/445 ,  A01N43/40

CPC分类号： A61K31/445 ,  Y02A50/382 ,  Y02A50/397 ,  Y02A50/409

摘要： Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives.

公开(公告)号：EP2473046B1

公开(公告)日：2014-10-22

申请号：EP10814412.2

申请日：2010-09-01

申请人： United Therapeutics Corporation ,  THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

发明人： RAMSTEDT, Urban ,  KLOSE, Brennan ,  ZITZMANN, Nicole ,  DWEK, Raymond, A. ,  BUTTERS, Terry, D.

IPC分类号： A01N43/40 ,  A61K31/445 ,  A61P31/12

CPC分类号： A61K31/445

公开(公告)号：EP2473493B1

公开(公告)日：2014-04-30

申请号：EP10814414.8

申请日：2010-09-01

申请人： United Therapeutics Corporation ,  THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

发明人： RAMSTEDT, Urban ,  KLOSE, Brennan ,  ZITZMANN, Nicole ,  DWEK, Raymond, A. ,  BUTTERS, Terry, D.

IPC分类号： A61K31/445 ,  C07D307/48 ,  A61P31/20

CPC分类号： A61K31/445 ,  A61K31/452 ,  C07D211/46

公开(公告)号：EP2473482A1

公开(公告)日：2012-07-11

申请号：EP10814409.8

申请日：2010-09-01

申请人： United Therapeutics Corporation ,  THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

发明人： RAMSTEDT, Urban ,  KLOSE, Brennan ,  ZITZMANN, Nicole ,  DWEK, Raymond, A. ,  BUTTERS, Terry, D.

IPC分类号： C07D211/30

CPC分类号： A61K31/445 ,  A61K31/655 ,  C07D211/46

摘要： Provided are novel iminosugars and methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Orthomyxoviridae family using iminosugars, such as DNJ derivatives.

摘要翻译： 本发明提供新颖的亚氨基糖和治疗和/或预防由或使用亚氨基糖，如DNJ衍生物病毒属于正粘病毒科相关的疾病或病症的方法。

公开(公告)号：EP2473046A1

公开(公告)日：2012-07-11

申请号：EP10814412.2

申请日：2010-09-01

申请人： United Therapeutics Corporation ,  THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

发明人： RAMSTEDT, Urban ,  KLOSE, Brennan ,  ZITZMANN, Nicole ,  DWEK, Raymond, A. ,  BUTTERS, Terry, D.

IPC分类号： A01N43/40 ,  A61K31/445

CPC分类号： A61K31/445

摘要： Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Filoviridae family using iminosugars, such as DNJ derivatives.

摘要翻译： 提供了使用亚氨基糖例如DNJ衍生物治疗由属于丝裂病毒科的病毒引起的或与其相关的疾病或病症的方法。

公开(公告)号：EP2968300A1

公开(公告)日：2016-01-20

申请号：EP14762952.1

申请日：2014-03-14

申请人： Unither Virology, LLC

发明人： WARFIELD, Kelly ,  RAMSTEDT, Urban

IPC分类号： A61K31/445

CPC分类号： A61K31/445 ,  A01N43/40 ,  A61K31/655 ,  Y02A50/473

摘要： Provided are iminosugars having antibacterial properties and methods of treating and/or preventing bacterial infections with such iminosugars. The present disclosure relates to antibacterial compounds and, in particular, to iminosugars having antibacterial activity. One embodiment is a method of treating or preventing a bacterial infection comprising administering to a subject in need thereof an antibacterial effective amount of a compound of the following formula: or a pharmaceutically acceptable salt thereof.