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公开(公告)号：EP1661911B1
公开(公告)日：2012-11-07
申请号：EP04772501.5
申请日：2004-08-31
发明人： NAKASHIMA, Toshihiro c/o JURIDICAL FOUNDATION THE , SASAKI, Takumi c/o JURIDICAL FOUNDATION THE , NISHIHARA, Tsukasa c/o JURIDICAL FOUNDATION THE , TAKEMOTO, Sumiyo c/o JURIDICAL FOUNDATION THE , SAKATA, Atsuko , OHKUCHI, Masao , KOSHI, Tomoyuki , EDANO, Toshiyuki
IPC分类号： C07K14/31 , A61K39/085 , A61P37/08 , C12N15/31
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公开(公告)号：EP1661911B8
公开(公告)日：2013-02-13
申请号：EP04772501.5
申请日：2004-08-31
发明人： NAKASHIMA, Toshihiro c/o JURIDICAL FOUNDATION THE , SASAKI, Takumi c/o JURIDICAL FOUNDATION THE , NISHIHARA, Tsukasa c/o JURIDICAL FOUNDATION THE , TAKEMOTO, Sumiyo c/o JURIDICAL FOUNDATION THE , SAKATA, Atsuko , OHKUCHI, Masao , KOSHI, Tomoyuki , EDANO, Toshiyuki
IPC分类号： C07K14/31 , A61K39/085 , A61P37/08 , C12N15/31
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3.发明公开PROTEASE-RESISTANT SEB VARIANT AND VACCINE CONTAINING THE SAME 有权耐腐蚀SEB-VARIANTE在DIESE ENTHALTENDER IMPFSTOFF
公开(公告)号：EP1661911A1
公开(公告)日：2006-05-31
申请号：EP04772501.5
申请日：2004-08-31
发明人： NAKASHIMA, Toshihiro c/o JURIDICAL FOUNDATION THE , SASAKI, Takumi c/o JURIDICAL FOUNDATION THE , NISHIHARA, Tsukasa c/o JURIDICAL FOUNDATION THE , TAKEMOTO, Sumiyo c/o JURIDICAL FOUNDATION THE , SAKATA, Atsuko , OHKUCHI, Masao , KOSHI, Tomoyuki , EDANO, Toshiyuki
IPC分类号： C07K14/31 , A61K39/085 , A61P37/08 , C12N15/31
摘要： A modified Staphylococcal enterotoxin B (SEB) having resistance to a protease and a reduced toxicity and a vaccine comprising said modified SEB are provided. A modified SEB which has an amino acid sequence as set forth in SEQ ID NO: 1 wherein each of the lysine at 97-position and the lysine at 98-position are substituted with any other amino acid, or a derivative thereof and a vaccine comprising said modified SEB or a derivative thereof.
摘要翻译： 提供了具有对蛋白酶的抗性和毒性降低的改良的葡萄球菌肠毒素B（SEB）和包含所述修饰的SEB的疫苗。 具有如SEQ ID NO：1所示的氨基酸序列的修饰SEB，其中97位的赖氨酸和98位的赖氨酸被任何其它氨基酸或其衍生物取代，并且包含 所述经修饰的SEB或其衍生物。
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