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公开(公告)号：EP2349854A1
公开(公告)日：2011-08-03
申请号：EP09741168.0
申请日：2009-10-23
CPC分类号： B65D23/00 , A47G19/2233 , B29B11/14 , B29B2911/1402 , B29B2911/14026 , B29B2911/14033 , B29B2911/1404 , B29B2911/14106 , B29B2911/1434 , B29B2911/14346 , B29B2911/1444 , B29B2911/14466 , B29B2911/14486 , B29C49/12 , B29K2105/258 , B29L2031/7158 , B65D85/73
摘要： A container (100) with a carbonated fluid therein. The container (100) may include a base (120) and a sidewall (130) positioned about the base. The base (120) and/or the sidewall (130) may include a number of nucleation sites (170) thereon. The nuclealion (170) sites may be positioned to form a number of bubbles (180) in a pattern (200) when the container is opened.
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2.发明授权METHODS FOR IDENTIFYING MODULATORS OF RGS21 ACTIVITY, COMPOSITIONS COMPRISING AN RGS21 MODULATOR, AND METHODS OF USE THEREOF TO MODULATE TASTE SENSATION 有权一种鉴定活动RGS21，具有RGS21调节剂组合物和方法调节剂类使用在调制味觉障碍
公开(公告)号：EP2054523B1
公开(公告)日：2015-11-18
申请号：EP07813415.2
申请日：2007-07-26
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
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公开(公告)号：EP2742350B1
公开(公告)日：2019-10-30
申请号：EP12748330.3
申请日：2012-08-08
发明人： RADHAKRISHNA, Harish , BROWN, Michael D. , SIDEROVSKI, David Peter , COHEN, Staci , KIMPLE, Adam
IPC分类号： G01N33/50
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公开(公告)号：EP2742350A1
公开(公告)日：2014-06-18
申请号：EP12748330.3
申请日：2012-08-08
发明人： RADHAKRISHNA, Harish , BROWN, Michael D. , SIDEROVSKI, David Peter , COHEN, Staci , KIMPLE, Adam
IPC分类号： G01N33/50
摘要： Provided herein are cell lines and assays that can be utilized to identify taste receptor modulators.
摘要翻译： 中的细胞系提供和测定法也可以用于标识关键受体调节剂。
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公开(公告)号：EP2742349A1
公开(公告)日：2014-06-18
申请号：EP12748329.5
申请日：2012-08-08
发明人： RADHAKRISHNA, Harish , BROWN, Michael D. , SIDEROVSKI, David Peter , COHEN, Staci , KIMPLE, Adam
IPC分类号： G01N33/50
CPC分类号： G01N33/502 , G01N2333/726 , G01N2500/10
摘要： Provided herein are cell lines and assays that can be utilized to identify taste receptor modulators.
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6.发明公开METHODS FOR IDENTIFYING MODULATORS OF RGS21 ACTIVITY, COMPOSITIONS COMPRISING AN RGS21 MODULATOR, AND METHODS OF USE THEREOF TO MODULATE TASTE SENSATION 有权一种鉴定活动RGS21，具有RGS21调节剂组合物和方法调节剂类使用在调制味觉障碍
公开(公告)号：EP2054523A2
公开(公告)日：2009-05-06
申请号：EP07813415.2
申请日：2007-07-26
IPC分类号： C12Q1/48
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
摘要： The present invention provides methods for identifying compounds that selectively and specifically modulate RGS21 gene expression, RGS21 protein expression, and/or the interaction of RGS2 I with G proteins in taste signal transduction. In particular, the present invention provides methods for identifying modulators of RGS21 activity for enhancing sweet taste, or other taste perception. Compositions comprising modulators of RGS21 activity for modulating taste signaling transduction are also provided.
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7.发明公开MODEL TASTE CELLS AND METHODS OF USE FOR IDENTIFYING MODULATORS OF TASTE SENSATION 审中-公开MODEL味觉细胞及用于鉴定味觉调节剂
公开(公告)号：EP2046829A2
公开(公告)日：2009-04-15
申请号：EP07799884.7
申请日：2007-07-27
IPC分类号： C07K14/705 , G01N33/566 , G01N33/53
CPC分类号： G01N33/5041 , G01N2333/726
摘要： The present invention provides model taste cells that naturally or recombinant Iy express taste receptors and relevant cellular proteins and/or molecules useful for taste signal transduction. The present invention further provides methods of use for these model taste cells for screening for compounds that modulate sweet and/or other taste signal transduction. Compositions comprising the compounds/modulators identified using the model taste cells are also provided. In preferred embodiments, the model taste cells are derived from human HuTu-80 enteroendocrine cells, and derivative cells thereof.
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