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    Screening methods using G-protein coupled receptors and related compositions
    4.
    发明公开
    Screening methods using G-protein coupled receptors and related compositions 有权
    筛选者G-protein-gekoppelten Rezeptoren und entsprechende Zusammensetzungen

    公开(公告)号：EP2650009A2

    公开(公告)日：2013-10-16

    申请号：EP13001965.6

    申请日：2008-08-01

    申请人： The General Hospital Corporation ,  Chugai Pharmaceutical Co., Ltd.

    发明人： Gardella, Thomas J. ,  Potts, John T. ,  Shimizu, Masaru ,  Ichikawa, Fumihiko ,  Jüppner, Harald ,  Okazaki, Makoto

    IPC分类号： A61K38/04 ,  A61K38/00 ,  G01N33/50 ,  G01N33/74

    CPC分类号： G01N33/56966 ,  A61K38/00 ,  A61K49/00 ,  C07K14/635 ,  C07K14/723 ,  G01N33/74 ,  G01N2333/645 ,  G01N2333/726

    摘要： The present invention relates to a polypeptide, or pharmaceutically acceptable salt thereof, comprising the formula PTH(1-X)/PTHrP(Y-36). Further, the present invention refers to a polypeptide which binds the PTH receptor and has a high affinity for the R 0 form of the PTH receptor and to a polypeptide having affinity for PTH RG and a low affinity for PTH R 0 . Moreover, the present invention includes to a pharmaceutical composition comprising such polypeptide. The present invention further relates to a polypeptide or a pharmaceutical composition of the present invention for use in a method for treating a disease or condition. Moreover, the present invention refers to a nucleic acid comprising a sequence encoding a polypeptide of the present invention, a vector comprising said nucleic acid, a cell comprising said vector and a method of making a polypeptide of the present invention. Finally, the present invention further relates to a method for determining whether a candidate compound is a long-acting agonist of a G protein coupled receptor (GPCR).

    摘要翻译： 本发明涉及包含式PTH（1-X）/ PTHrP（Y-36）的多肽或其药学上可接受的盐。 此外，本发明涉及结合PTH受体并对R 0形式的PTH受体具有高亲和力的多肽，以及对PTH RG具有亲和性且对PTH R 0具有低亲和力的多肽。 此外，本发明包括包含这种多肽的药物组合物。 本发明还涉及用于治疗疾病或病症的方法的本发明的多肽或药物组合物。 此外，本发明涉及包含编码本发明多肽的序列，包含所述核酸的载体，包含所述载体的细胞和制备本发明的多肽的方法的核酸。 最后，本发明还涉及一种用于确定候选化合物是否为G蛋白偶联受体（GPCR）的长效激动剂的方法。