公开(公告)号：EP2461825B1

公开(公告)日：2017-05-31

申请号：EP10807108.5

申请日：2010-08-04

申请人： The Government of The United States of America, as represented by the Secretary, Department of Health and Human Services, ,  The University of Georgia Research Foundation

发明人： ANDERSON, Larry J. ,  HAYNES, Lia M. ,  TRIPP, Ralph A.

IPC分类号： A61K39/155 ,  C07K14/115 ,  A61K39/12 ,  C07K14/135

CPC分类号： C07K14/135 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/555 ,  A61K2039/55505 ,  A61K2039/6081 ,  C07K14/005 ,  C12N2760/18522 ,  C12N2760/18534

公开(公告)号：EP2461825A2

公开(公告)日：2012-06-13

申请号：EP10807108.5

申请日：2010-08-04

申请人： The Government of The United States of America, as represented by the Secretary, Department of Health and Human Services,

发明人： ANDERSON, Larry J. ,  HAYNES, Lia M. ,  TRIPP, Ralph A.

IPC分类号： A61K39/155 ,  C07K14/115 ,  A61K39/12

CPC分类号： C07K14/135 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/555 ,  A61K2039/55505 ,  A61K2039/6081 ,  C07K14/005 ,  C12N2760/18522 ,  C12N2760/18534

摘要： Immunogenic polypeptides corresponding to one or more RSV G glycoproteins, or analogues thereof, are provided as components of vaccines. The inventive compositions are useful as both a prophylactic and therapeutic for the prevention and treatment of RSV infections and associated pulmonary or other diseases. The inventive immunogens include regions of the RSV G protein, specifically, amino acid residues 164-176 of RSV G A2 protein or analogues thereof. This inventive immunogen is operable alone or in combination with other polypeptides such as the RSV G protein amino acid residues 155-206, or other vaccines such as live RSV vaccines, or inactivated RSV vaccines or immunogenic analogues thereof.

摘要翻译： 对应于一种或多种RSV G糖蛋白或其类似物的免疫原性多肽作为疫苗的组分提供。 本发明的组合物可用作预防和治疗RSV感染和相关肺或其它疾病的预防和治疗。 本发明的免疫原包括RSV G蛋白的区域，特别是RSV G A2蛋白的氨基酸残基164-176或其类似物。 本发明的免疫原可单独使用或与其它多肽如RSV G蛋白氨基酸残基155-206或其它疫苗例如活RSV疫苗或灭活的RSV疫苗或其免疫原性类似物组合使用。