专利检索 ap:("The Government of The United States of America as represented by the Secretary of The Department of Health AND Human Services, Centers for Disease") AND inv:"KSIAZEK, Thomas, G." 第 1 页

1.

发明授权
RECOMBINANT RIFT VALLEY FEVER (RVF) VIRUSES AND METHODS OF USE 有权
标题翻译：重组裂谷热（RVF）病毒及其使用方法

公开(公告)号：EP2240201B1

公开(公告)日：2015-04-22

申请号：EP08863946.3

申请日：2008-12-16

申请人： The Government of The United States of America as represented by the Secretary of The Department of Health and Human Services, Centers for Disease

发明人： BIRD, Brian, H. , ALBARINO, Cesar, G. , NICHOL, Stuart, T. , KSIAZEK, Thomas, G.

IPC分类号： A61K39/12

CPC分类号： A61K39/12 , A61K35/76 , A61K39/00 , A61K2039/525 , A61K2039/5254 , C12N7/00 , C12N2760/12211 , C12N2760/12221 , C12N2760/12234 , Y02A50/397

摘要： Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.

2.

发明公开
RECOMBINANT RIFT VALLEY FEVER (RVF) VIRUSES AND METHODS OF USE 有权
标题翻译：重组裂谷热（RVF）病毒及其使用方法

公开(公告)号：EP2240201A2

公开(公告)日：2010-10-20

申请号：EP08863946.3

申请日：2008-12-16

申请人： The Government of The United States of America as represented by the Secretary of The Department of Health and Human Services, Centers for Disease

发明人： BIRD, Brian, H. , ALBARINO, Cesar, G. , NICHOL, Stuart, T. , KSIAZEK, Thomas, G.

IPC分类号： A61K39/12

CPC分类号： A61K39/12 , A61K35/76 , A61K39/00 , A61K2039/525 , A61K2039/5254 , C12N7/00 , C12N2760/12211 , C12N2760/12221 , C12N2760/12234 , Y02A50/397

摘要： Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.