公开(公告)号：EP3205352A1

公开(公告)日：2017-08-16

申请号：EP17155603.8

申请日：2003-04-25

申请人： The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Whitehead, Stephen S. ,  Murphy, Brian R. ,  Markoff, Lewis ,  Falgout, Barry ,  Blaney, Joseph ,  Hanley, Kathryn ,  Lai, Ching-Juh

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  C12N7/00 ,  C07H21/04

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N2770/24134 ,  C12N2770/24161 ,  Y02A50/386

摘要： The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (Δ30) in the 3'-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.

摘要翻译： 本发明涉及登革病毒四价疫苗，其在登革病毒血清型1,2,3和4的基因组的3'非翻译区或血清型1，2，3和4的抗原嵌合登革病毒中含有共同的30个核苷酸缺失（Δ30） 2,3和4。

公开(公告)号：EP2338508A1

公开(公告)日：2011-06-29

申请号：EP10177735.7

申请日：2003-04-25

申请人： The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Whitehead, Stephen S. ,  Murphy, Brian R. ,  Markoff, Lewis ,  Falgout, Barry ,  Blaney, Joseph ,  Hanley, Kathryn

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  C12N7/00 ,  C07H21/04

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N2770/24134 ,  C12N2770/24161 ,  Y02A50/386

摘要： A rDEN3/4Δ30(ME), rDEN2/4Δ30(ME) or rDEN1/4Δ30(ME) recombinant chimeric dengue virus containing a 30 nucleotide deletion (Δ30) in a section of the 3' untranslated region of dengue type 4 genome, where said 30 nucleotide deletion corresponds to the TL2 stem-loop structure.

摘要翻译： 甲RDEN3 / 4 “30（ME），rDEN2 / 4” 30（ME）或rDEN1 / 4 “30（ME）的重组嵌合登革病毒含有一个30个核苷酸缺失的3“非翻译的区域的截面（” 30） 登革热4型基因组中，其中，所述30个核苷酸缺失对应于TL2茎 - 环结构。

公开(公告)号：EP3763382A1

公开(公告)日：2021-01-13

申请号：EP20153909.5

申请日：2003-04-25

申请人： The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： Whitehead, Stephen S. ,  Murphy, Brian R. ,  Markoff, Lewis ,  Falgout, Barry ,  Blaney, Joseph ,  Hanley, Kathryn ,  Lai, Ching-Juh

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  C12N7/00 ,  C07H21/04

摘要： The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (Δ30) in the 3'-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.

公开(公告)号：EP2338508B1

公开(公告)日：2018-02-14

申请号：EP10177735.7

申请日：2003-04-25

申请人： The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Whitehead, Stephen S. ,  Murphy, Brian R. ,  Markoff, Lewis ,  Falgout, Barry ,  Blaney, Joseph ,  Hanley, Kathryn ,  Lai, Ching-Juh

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  C12N7/00 ,  C07H21/04

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N2770/24134 ,  C12N2770/24161 ,  Y02A50/386

摘要： A rDEN3/4”30(ME), rDEN2/4”30(ME) or rDEN1/4”30(ME) recombinant chimeric dengue virus containing a 30 nucleotide deletion (”30) in a section of the 3' untranslated region of dengue type 4 genome, where said 30 nucleotide deletion corresponds to the TL2 stem-loop structure.