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公开(公告)号：EP2704739A1
公开(公告)日：2014-03-12
申请号：EP12722586.0
申请日：2012-05-04
发明人： PASTAN, Ira H. , WELDON, John , BEERS, Richard
CPC分类号： C07K16/30 , A61K39/0011 , A61K47/6829 , A61K47/6851 , C07K14/21 , C07K2317/56 , C07K2319/32 , C07K2319/50 , C07K2319/55 , C07K2319/70
摘要： Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to improved recombinant immunotoxins comprising anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and a Pseudomonas Exotoxin moiety which has been modified to reduce its immunogenicity and protease sensitivity and providing a better cytotoxicity for cells which expresss mesothelin. The RITs are well-suited for the treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
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公开(公告)号：EP2704739B1
公开(公告)日：2017-07-12
申请号：EP12722586.0
申请日：2012-05-04
发明人： PASTAN, Ira H. , WELDON, John , BEERS, Richard
CPC分类号： C07K16/30 , A61K39/0011 , A61K47/6829 , A61K47/6851 , C07K14/21 , C07K2317/56 , C07K2319/32 , C07K2319/50 , C07K2319/55 , C07K2319/70
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3.发明授权
公开(公告)号：EP0703926B1
公开(公告)日：1998-08-19
申请号：EP94921956.2
申请日：1994-06-14
IPC分类号： C07K16/00 , C07K14/705 , A61K47/48
CPC分类号： C07K14/7051 , A61K38/00 , A61K47/6829 , A61K47/6835 , C07K16/00 , C07K2319/00 , C07K2319/33 , C07K2319/55 , Y10S530/866 , Y10S530/867
摘要： The present invention relates to disulfide-stabilized recombinant polypeptide molecules which have the binding ability and specificity for another peptide, such as the variable region of an antibody molecule. Methods of producing these molecules and nucleic acid sequences encoding these molecules are also described. In particular, the invention discloses Fv antibody fragments stabilized by a disulfide bond connecting the VH and VL regions of the Fv fragment. The alpha and beta chains of T cells receptors may be similarly stabilized by means described in the invention.
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4.发明公开
公开(公告)号：EP0703926A1
公开(公告)日：1996-04-03
申请号：EP94921956.0
申请日：1994-06-14
CPC分类号： C07K14/7051 , A61K38/00 , A61K47/6829 , A61K47/6835 , C07K16/00 , C07K2319/00 , C07K2319/33 , C07K2319/55 , Y10S530/866 , Y10S530/867
摘要： The present invention relates to disulfide-stabilized recombinant polypeptide molecules which have the binding ability and specificity for another peptide, such as the variable region of an antibody molecule. Methods of producing these molecules and nucleic acid sequences encoding these molecules are also described. In particular, the invention discloses Fv antibody fragments stabilized by a disulfide bond connecting the VH and VL regions of the Fv fragment. The α and β chains of T cells receptors may be similarly stabilized by means described in the invention.
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公开(公告)号：EP2475398A1
公开(公告)日：2012-07-18
申请号：EP10755283.8
申请日：2010-09-10
发明人： PASTAN, Ira H. , BEERS, Richard , ONDA, Masanori
摘要： The present invention provides improved
Pseudomonas Exotoxin A (PE) molecules with high cytotoxicity and reduced immunogenicity, compositions containing the improved (PE), and methods of use.-
公开(公告)号：EP2475398B1
公开(公告)日：2015-05-20
申请号：EP10755283.8
申请日：2010-09-10
发明人： PASTAN, Ira H. , BEERS, Richard , ONDA, Masanori
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