公开(公告)号：EP2630242B1

公开(公告)日：2017-08-02

申请号：EP11835004.0

申请日：2011-10-18

申请人： The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services,

发明人： SMITH, Todd, G. ,  WU, Xianfu

IPC分类号： C12N15/13 ,  C07K16/00 ,  G01N33/53 ,  A61K39/395 ,  C12N15/85 ,  G01N33/569 ,  C07K16/10

CPC分类号： C07K16/10 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C12N2760/20145 ,  C12N2810/6081 ,  C12Q1/00 ,  G01N33/56983 ,  G01N2333/145 ,  G01N2500/10

摘要： Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.

摘要翻译： 本文描述了鉴定特异性结合多种狂犬病病毒的单克隆抗体（或其抗原结合片段）以用于暴露后狂犬病预防或用于治疗临床狂犬病的方法。 该方法包括使用初始抗体噬菌体展示文库来筛选结合完整重组狂犬病毒的噬菌体克隆或表达来自多个狂犬病病毒（例如RABV，MOKV和WCBV）的糖蛋白的细胞和/或特异性结合来自不同狂犬病病毒的重组糖蛋白。

公开(公告)号：EP2630242A1

公开(公告)日：2013-08-28

申请号：EP11835004.0

申请日：2011-10-18

申请人： The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services,

发明人： SMITH, Todd, G. ,  WU, Xianfu

IPC分类号： C12N15/13 ,  C07K16/00 ,  G01N33/53 ,  A61K39/395 ,  C12N15/85

CPC分类号： C07K16/10 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C12N2760/20145 ,  C12N2810/6081 ,  C12Q1/00 ,  G01N33/56983 ,  G01N2333/145 ,  G01N2500/10

摘要： Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.

摘要翻译： 本文描述了鉴定特异性结合多种狂犬病病毒的单克隆抗体（或其抗原结合片段）用于暴露后狂犬病预防或用于临床狂犬病治疗的方法。 该方法包括使用幼稚抗体噬菌体展示文库来筛选结合完整重组狂犬病毒的噬菌体克隆或表达来自多个狂犬病病毒（例如RABV，MOKV和WCBV）的糖蛋白的细胞和/或特异性结合来自不同狂犬病病毒的重组糖蛋白。