公开(公告)号：EP1940867A2

公开(公告)日：2008-07-09

申请号：EP06814287.6

申请日：2006-09-06

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services ,  Dana Farber Cancer Institute, Inc. ,  THE SCRIPPS RESEARCH INSTITUTE

发明人： KWONG, Peter, D. ,  ZHOH, Tongqing ,  XU, Ling ,  NABEL, Gary ,  DEY, Barna ,  WYATT, Richard ,  XIANG, Shi-Hua ,  SODROSKI, Joseph ,  BURTON, Dennis ,  ARTHOS, James

IPC分类号： C07K14/16 ,  C12N15/49 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  C07K14/70514 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present disclosure relates to stabilized forms of the HIV gpl20 envelope protein in complex with the broadly neutralizing CD4-binding site antibody bl2, to crystalline forms of the stabilized forms of the HIV gpl20 envelope protein in complex with the broadly neutralizing CD4- binding site antibody b 12, and to the high resolution structure obtained from these crystals by X-ray diffraction methods. Methods for identifying immunogenic polypeptides based on these structures are also disclosed.

公开(公告)号：EP2618843B1

公开(公告)日：2016-12-07

申请号：EP11827599.9

申请日：2011-09-23

申请人： International Aids Vaccine Initiative ,  The Scripps Research Institute ,  National Institutes Of Health

发明人： MASCOLA, John ,  BURTON, Dennis R. ,  KOFF, Wayne ,  KWONG, Peter ,  NABEL, Gary ,  PHOGAT, Sanjay K. ,  POIGNARD, Pascal Raymond Georges ,  SIMEK-LEMOS, Melissa Danielle De Jean De St. Marcel ,  WU, Xueling ,  YANG, Zhi-Yong ,  ZHOU, Tongqing

IPC分类号： A61K39/42 ,  C07K16/10 ,  A61P31/18

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56988

摘要： The present application relates broadly neutralizing monoclonal antibodies directed against HIV-1. In particular, monoclonal antibodies VRC-PG04 and VRC-PG05 are disclosed.

摘要翻译： 本申请涉及针对HIV-1的广泛中和单克隆抗体。 特别地，公开了单克隆抗体VRC-PG04和VRC-PG05。

公开(公告)号：EP2618843A2

公开(公告)日：2013-07-31

申请号：EP11827599.9

申请日：2011-09-23

申请人： International Aids Vaccine Initiative ,  The Scripps Research Institute ,  National Institutes Of Health

发明人： MASCOLA, John ,  BURTON, Dennis R. ,  KOFF, Wayne ,  KWONG, Peter ,  NABEL, Gary ,  PHOGAT, Sanjay K. ,  POIGNARD, Pascal Raymond Georges ,  SIMEK-LEMOS, Melissa Danielle De Jean De St. Marcel ,  WU, Xueling ,  YANG, Zhi-Yong ,  ZHOU, Tongqing

IPC分类号： A61K39/42

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56988

摘要： The present application relates broadly neutralizing monoclonal antibodies directed against HIV-1. In particular, monoclonal antibodies VRC-PG04 and VRC-PG05 are disclosed.