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公开(公告)号：EP3177320A1
公开(公告)日：2017-06-14
申请号：EP15827008.2
申请日：2015-07-31
申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services , The Hong Kong University of Science and Technology
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K39/39558 , C07K14/71 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/76 , C07K2319/30 , G01N33/57492 , G01N33/6896 , G01N2800/52
摘要： The present invention provides new, fully human EphA4 monoclonal antibodies with distinct binding characteristics. Also disclosed are antigen binding fragments of these antibodies, bispecific forms of these antibodies, and conjugates of these antibodies. In addition, nucleic acids encoding these antibodies, antigen binding fragments, bispecific antibodies and conjugates are disclosed. These monoclonal antibodies, antigen binding fragments, bispecific antibodies, conjugates, nucleic acids and vectors are of use for identifying and treating a subject with a disease or condition involving abnormal EphA4-mediated signaling.
摘要翻译： 本发明提供具有不同结合特征的新的完全人EphA4单克隆抗体。 还公开了这些抗体的抗原结合片段，这些抗体的双特异性形式以及这些抗体的缀合物。 另外，公开了编码这些抗体，抗原结合片段，双特异性抗体和缀合物的核酸。 这些单克隆抗体，抗原结合片段，双特异性抗体，缀合物，核酸和载体可用于鉴定和治疗患有涉及异常EphA4介导的信号传导的疾病或病症的受试者。
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公开(公告)号：EP3473271A1
公开(公告)日：2019-04-24
申请号：EP18209632.1
申请日：2015-07-31
申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services , The Hong Kong University of Science and Technology
IPC分类号： A61K39/395 , C07K16/28 , A61P25/28 , A61P35/00
摘要： The present invention provides new, fully human EphA4 monoclonal antibodies with distinct binding characteristics. Also disclosed are antigen binding fragments of these antibodies, bispecific forms of these antibodies, and conjugates of these antibodies. In addition, nucleic acids encoding these antibodies, antigen binding fragments, bispecific antibodies and conjugates are disclosed. These monoclonal antibodies, antigen binding fragments, bispecific antibodies, conjugates, nucleic acids and vectors are of use for identifying and treating a subject with a disease or condition involving abnormal EphA4-mediated signaling.
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