公开(公告)号：EP2417268B1

公开(公告)日：2016-05-11

申请号：EP10749365.2

申请日：2010-03-05

申请人： The Johns Hopkins University

发明人： VOGELSTEIN, Bert ,  KINZLER, Kenneth W. ,  PARSONS, D. Williams ,  JONES, Sian ,  KERN, Scott ,  HRUBAN, Ralph ,  ESHLEMAN, James R. ,  GOGGINS, Michael ,  KLEIN, Alison ,  HIDALGO, Manuel ,  VELCULESCU, Victor E.

IPC分类号： C12Q1/68 ,  G01N33/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  A61K31/407 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57438 ,  G01N2333/47

公开(公告)号：EP2417268A2

公开(公告)日：2012-02-15

申请号：EP10749365.2

申请日：2010-03-05

申请人： The Johns Hopkins University

发明人： VOGELSTEIN, Bert ,  KINZLER, Kenneth W. ,  PARSONS, D. Williams ,  JONES, Sian ,  KERN, Scott ,  HRUBAN, Ralph ,  ESHLEMAN, James R. ,  GOGGINS, Michael ,  KLEIN, Alison ,  HIDALGO, Manuel ,  VELCULESCU, Victor E.

IPC分类号： C12Q1/68 ,  G01N33/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  A61K31/407 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57438 ,  G01N2333/47

摘要： The present invention provides a method for detecting mutations in the
PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a
PALB2 mutation or abberant
PALB2 gene expression in a patient.