专利检索 ap:("The Johns Hopkins University") AND inv:"JAIN, Sanjay K." 第 1 页

1.

发明公开
BACTERIA-SPECIFIC LABELED SUBSTRATES AS IMAGING BIOMARKERS TO DIAGNOSE, LOCATE, AND MONITOR INFECTIONS 审中-公开
标题翻译：细菌具体注明为底物BILDGEBUNGSBIOMARKER诊断，隔离和感染的监测

公开(公告)号：EP2895205A1

公开(公告)日：2015-07-22

申请号：EP13837073.9

申请日：2013-09-16

申请人： The Johns Hopkins University

发明人： JAIN, Sanjay K. , POMPER, Martin Gilbert , WEINSTEIN, Edward A. , ORDONEZ, Alvaro , KLUNIK, Mariah

IPC分类号： A61K51/04 , A61K51/02 , A61K51/00

CPC分类号： A61K51/0491 , A61K51/0402

摘要： The methods of the present invention exploit unique biochemical pathways present within infectious organisms to develop small molecule metabolic tracers. Labeled substrates created using these inventive methods were created. The labeled substrates can be used to determine whether a subject is infected with an infectious organism by imaging means, and with use of two or more such labeled substrates, methods of differentiating gram negative infection from gram positive infection, and methods of localizing and quantifying infectious disease burden are provided. The methods of the present invention can assist in the clinical decision to begin empiric antibiotic therapy, determine its efficacy, as well as the choice of antibacterial agents.