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1.发明授权TRUNCATED VARIANT OF THE MAMMALIAN TARGET FOR RAPAMYCIN (MTOR) PROTEIN 有权GEKÜRZTEVARIANTE DES PROTEINS DESSÄUGETIER-TARGETSFÜRRAPAMYCIN（MTAM的RAPAMYCIN MAMMALIAN TARGET）
公开(公告)号：EP2139914B1
公开(公告)日：2017-03-01
申请号：EP08737164.7
申请日：2008-05-01
IPC分类号： C07K14/705 , C12Q1/48 , C12N9/12 , C07K14/47
CPC分类号： C12N9/12 , C07K14/4702 , C07K14/705 , C07K16/40 , C07K2317/24 , C07K2317/76 , C12P21/02 , C12Q1/485 , C12Q1/6876 , C12Q2600/156 , C12Q2600/158 , C12Y207/11001 , G01N33/5008 , G01N2440/14
摘要： The invention relates to mTORbeta, a splice form of mTOR, nucleic acids encoding mTOR beta, and antibodies against mTOR beta. The invention also relates to methods of producing mTOR beta and methods of screening for an agent that modulates mTOR beta expression and/or activity. The invention further relates to a method of treating a disease associated with aberrant expression of mTOR beta by administration of an agent that alters mTOR activity and/or expression.
摘要翻译： 本发明涉及mTORbeta，mTOR的剪接形式，编码mTORβ的核酸和针对mTORβ的抗体。 本发明还涉及产生mTORβ的方法和筛选调节mTORβ表达和/或活性的试剂的方法。 本发明还涉及通过施用改变mTOR活性和/或表达的试剂来治疗与mTORβ异常表达相关的疾病的方法。
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2.发明公开TRUNCATED VARIANT OF THE MAMMALIAN TARGET FOR RAPAMYCIN (MTOR) PROTEIN 有权哺乳动物靶的蛋白质的删节版雷帕霉素（哺乳动物靶雷帕霉素，MTOR）
公开(公告)号：EP2139914A1
公开(公告)日：2010-01-06
申请号：EP08737164.7
申请日：2008-05-01
IPC分类号： C07K14/47
CPC分类号： C12N9/12 , C07K14/4702 , C07K14/705 , C07K16/40 , C07K2317/24 , C07K2317/76 , C12P21/02 , C12Q1/485 , C12Q1/6876 , C12Q2600/156 , C12Q2600/158 , C12Y207/11001 , G01N33/5008 , G01N2440/14
摘要： The invention relates to mTORbeta, a splice form of mTOR, nucleic acids encoding mTOR beta, and antibodies against mTOR beta. The invention also relates to methods of producing mTOR beta and methods of screening for an agent that modulates mTOR beta expression and/or activity. The invention further relates to a method of treating a disease associated with aberrant expression of mTOR beta by administration of an agent that alters mTOR activity and/or expression.
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