公开(公告)号：EP2095100A1

公开(公告)日：2009-09-02

申请号：EP07873479.5

申请日：2007-11-19

申请人： The President and Fellows of Harvard College

发明人： LIEBER, Charles, M. ,  GAO, Xuan, P.a. ,  ZHENG, Gengfeng

IPC分类号： G01N27/414

CPC分类号： G01N33/552 ,  B82Y15/00 ,  B82Y30/00 ,  G01N27/4146

摘要： The present invention generally relates to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample. The invention provides a nanoscale wire that has improved sensitivity, as the carrier concentration in the wire is controlled by an external gate voltage, such that the nanoscale wire has a Debye screening length that is greater than the average cross- sectional dimension of the nanoscale wire when the nanoscale wire is exposed to a solution suspected of containing an analyte. This Debye screening length ( lambda) associated with the carrier concentration (p) inside nanoscale wire is adjusted by adjusting the gate voltage applied to an FET structure, such that the carriers in the nanoscale wire are depleted.