摘要:
A cosmetic method for reducing the level of High-Mobility Group Protein B1 released from keratinocytes. The method includes identifying a target portion of skin where reduction of HMGB1 level is desired, and topically applying a nicotinamide riboside containing cosmetic composition to the target portion of skin during a treatment period, which is sufficient to reduce the level of HMGB1 released by keratinocytes. By reducing HMGB1 protein level, melanocyte dendricity can be reduced, thereby resulting in less melanin being taken into keratinocytes. The reduction in melanin transfer may provide a way to treat skin pigmentation disorders such as hyperpigmented spots.
摘要:
A method of identifying a test agent as a skin tone agent. The method includes determining the level of high-mobility group protein B1 (HMGB1), messenger RNA associated with the expression and/or regulation of HMGB1 (HMGB1 mRNA), and/or micro-RNA associated with the expression and/or regulation of HMGB1 (HMGB1 miRNA) present in the test sample, and identifying the test agent as a skin tone agent when there is no increase in HMGB1 level, a downregulation in transcription of HMGB1 mRNA, and/or an upregulation of HMGB1 miRNA. The method also includes identifying a test agent as a skin tone agent when the test agent inhibits or prevents an increase in melanocyte dendricity and/or body size caused by HMGB1.
摘要:
A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis (2-ethylhexyl) sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.
摘要:
A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using said cosmetic compositions is also disclosed herein.
摘要:
A method of improving the appearance of facial pores is provided. The method includes the step of applying a composition having an effective amount of a material that regulates IL-1 and/or hyaluronic acid synthesis to an area of facial pores, wherein the composition is applied for a period of time sufficient for the material to improve the appearance of the facial pores. In some embodiments, the material that regulates IL-1 and/or hyaluronic acid synthesis is hexyldecanol. The method may also include the step of identifying facial pores on a facial skin surface.
摘要:
The present invention provides cosmetic compositions comprising Ficus serum fraction derived from fresh Ficus cell juice of fresh Ficus leaves. The cosmetic composition also comprises a cosmetically acceptable carrier. The Ficus serum fraction is present in the composition at a cosmetically effective amount for achieving the desired skin lightening result.