-
公开(公告)号：EP3455370B1
公开(公告)日：2020-03-18
申请号：EP17724704.6
申请日：2017-05-09
IPC分类号： C12Q1/6876 , G01N33/68 , G01N33/50
-
公开(公告)号：EP3455370A1
公开(公告)日：2019-03-20
申请号：EP17724704.6
申请日：2017-05-09
摘要： Methods of identifying potential skin moisturizing actives for the treatment of dry skin and method of formulating a moisturizing skin care composition using actives identified by the method. Moisturizing agents can be identified by comparing the transcriptional profile of a skin tissue sample contacted by a test agent to a negative or positive control to determine if the regulation of certain genes corresponds to the appropriate direction of regulation indicated by the control. Agents identified as skin moisturizing agents can then be incorporated into a skin moisturizing composition.
-
公开(公告)号：EP2531614B1
公开(公告)日：2018-07-18
申请号：EP11706065.7
申请日：2011-02-07
发明人： FINLAY, Deborah, Ruth , BINDER, Robert, Lloyd , ROBINSON, Michael, Keith , OSBORNE, Rosemarie , MULLINS, Lisa, Ann
IPC分类号： C12Q1/6883
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158 , C12Q2600/16 , G01N33/5044 , G01N2333/90245 , G01N2500/04 , G01N2500/10
摘要： Gene panels, microarrays and biomarker panels relating to genes and gene products associated with age-related oxidative damage to skin, and transcriptional profiling-based methods for identification and evaluation of cosmetic agents for prevention, reversal, or reduction of oxidative damage to skin. Cosmetic agents and compositions comprising the cosmetic agents, capable of inducing nrf2-mediated activation of the antioxidant response element to increase expression of Phase 2 enzymes, methods for restoring optimal redox status to skin employing the agents, and methods for identifying and evaluating cosmetic agents acting via the nrf2-mediated mechanism.
-
4.发明公开TRANSCRIPTIONAL PROFILING AND BIOMARKER-BASED METHODS FOR IDENTIFYING AND EVALUATING AGENTS FOR ANTIOXIDANT EFFICACY IN COSMETIC SKIN CARE FORMULATIONS 有权对转录概况的有关其抗氧化作用的美容护肤品配方识别和评价物质的生产生物标志物化进程
公开(公告)号：EP2531614A1
公开(公告)日：2012-12-12
申请号：EP11706065.7
申请日：2011-02-07
发明人： FINLAY, Deborah, Ruth , BINDER, Robert, Lloyd , ROBINSON, Michael, Keith , OSBORNE, Rosemarie , MULLINS, Lisa, Ann
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158 , C12Q2600/16 , G01N33/5044 , G01N2333/90245 , G01N2500/04 , G01N2500/10
摘要： Gene panels, microarrays and biomarker panels relating to genes and gene products associated with age-related oxidative damage to skin, and transcriptional profiling-based methods for identification and evaluation of cosmetic agents for prevention, reversal, or reduction of oxidative damage to skin. Cosmetic agents and compositions comprising the cosmetic agents, capable of inducing nrf2-mediated activation of the antioxidant response element to increase expression of Phase 2 enzymes, methods for restoring optimal redox status to skin employing the agents, and methods for identifying and evaluating cosmetic agents acting via the nrf2-mediated mechanism.
摘要翻译： 基因面板，芯片和生物标志物组与基因和基因产物与年龄相关的氧化损伤皮肤，并为预防，逆转，或减少氧化损伤皮肤的化妆品代理商鉴定和评估基于转录分析的方法有关。 美容剂和组合物，其包括化妆品剂，能够诱导抗氧化反应元件的的Nrf2介导的活化，以增加第2阶段酶，最佳的氧化还原状态恢复到皮肤用人剂的方法，与方法的表达为识别和评估作用美容剂的 经由所述Nrf2介导的机制。
-
-
-
搜索结果
4 条记录 (耗时 0.011 秒)
