专利检索 ap:("The Regents of the University of California") AND inv:"MINAMISAWA, Susanne" 第 1 页

1.

发明授权
A MUTANT PHOSPHOLAMBAN MOLECULE AND ITS USE IN THE TREATMENT OF CARDIAC DISEASE AND HEART FAILURE 有权
标题翻译：突变磷蛋白分子及其用于心脏病和心力衰竭的治疗

公开(公告)号：EP1126866B1

公开(公告)日：2007-02-07

申请号：EP99960187.5

申请日：1999-11-02

申请人： The Regents of the University of California

发明人： CHIEN, Kenneth , DILLMAN, Wolfgang , MINAMISAWA, Susanne , HE, Huaping , HOSHIJIMA, Masahiko , MEYER, Markus , SCOTT, Christopher , WANG, Yibin , SILVERMAN, Gregg J.

IPC分类号： A61K38/17 , A61K47/48 , C07K17/00 , A61P9/04

CPC分类号： C07K14/47 , A01K2217/05 , A61K38/1709 , C07K2319/00 , C12N2799/022

2.

发明公开
A METHOD FOR INHIBITION OF PHOSPHOLAMBAN ACTIVITY FOR THE TREATMENT OF CARDIAC DISEASE AND HEART FAILURE 有权
标题翻译：突变磷蛋白分子及其用于心脏病和心力衰竭的治疗

公开(公告)号：EP1126866A2

公开(公告)日：2001-08-29

申请号：EP99960187.5

申请日：1999-11-02

申请人： The Regents of the University of California

发明人： CHIEN, Kenneth , DILLMAN, Wolfgang , MINAMISAWA, Susanne , HE, Huaping , HOSHIJIMA, Masahiko , MEYER, Markus , SCOTT, Christopher , WANG, Yibin , SILVERMAN, Gregg J.

IPC分类号： A61K38/17 , A61K47/48 , C07K17/00 , A61P9/04

CPC分类号： C07K14/47 , A01K2217/05 , A61K38/1709 , C07K2319/00 , C12N2799/022

摘要： The present invention provides a method for the treatment of heart failure through the use of small peptide complexes and recombinant proteins which function to enhance contractility in failing hearts and reduce blood pressure in individuals with hypertension by inhibiting the interaction between phospholamban and sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) within cardiomyocytes. In addition, a means is provided for the transport of such therapeutic agents into the cytoplasm and nucleus of cardiomyocytes.