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公开(公告)号：EP3252076A1
公开(公告)日：2017-12-06
申请号：EP17167174.6
申请日：2012-01-13
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , G01N33/574
CPC分类号： G01N33/6854 , A61K2039/505 , C07K16/2803 , C07K16/40 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
摘要翻译： 在癌细胞（特别是白血病和淋巴瘤细胞）上表达的对ROR-1具有结合特异性的治疗性抗体和含有一种或多种此类抗体的药物组合物用于治疗癌症。 还提供了通过体外检测与在推定的癌细胞上表达的ROR-1蛋白的结合来诊断这些癌症的方法。
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公开(公告)号：EP3885366A3
公开(公告)日：2021-12-29
申请号：EP21152464.0
申请日：2012-01-13
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , G01N33/574
摘要： Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
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公开(公告)号：EP3885366A2
公开(公告)日：2021-09-29
申请号：EP21152464.0
申请日：2012-01-13
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , G01N33/574
摘要： Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
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公开(公告)号：EP3604339A1
公开(公告)日：2020-02-05
申请号：EP19192973.6
申请日：2012-01-13
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
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公开(公告)号：EP3252076B1
公开(公告)日：2019-09-04
申请号：EP17167174.6
申请日：2012-01-13
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , G01N33/574
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6.发明授权THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND METHODS FOR USE OF SAME 有权针对ROR-1蛋白的治疗性抗体及使用该抗体的方法
公开(公告)号：EP2663579B1
公开(公告)日：2017-04-26
申请号：EP12734733.4
申请日：2012-01-13
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： G01N33/6854 , A61K2039/505 , C07K16/2803 , C07K16/40 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92
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7.发明公开
公开(公告)号：EP2663579A2
公开(公告)日：2013-11-20
申请号：EP12734733.4
申请日：2012-01-13
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： G01N33/6854 , A61K2039/505 , C07K16/2803 , C07K16/40 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
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