公开(公告)号：EP0954320A1

公开(公告)日：1999-11-10

申请号：EP97942600.0

申请日：1997-09-19

申请人： The Regents of the University of California ,  Inologic, Inc. ,  University Of California

发明人： TRAYNOR-KAPLAN, Alexis ,  SCHULTZ, Carsten ,  ROEMER, Stefan ,  STADLER, Christoph ,  RUDOLF, Marco

IPC分类号： A61K31 ,  A61P1 ,  A61P11 ,  A61P43 ,  C07F9

CPC分类号： A61K31/6615 ,  A61K31/683 ,  C07F9/117

摘要： The present invention provides compositions that are cell permeable antagonists of inositol polyphosphates. In addition, the invention provides methods for enhancing chloride ion secretion from a cell by contacting the cells with cell permeable antagonists of inositol polyphosphates. The invention also provides methods for enhancing chloride ion secretion in an individual by administering cell permeable antagonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with cystic fibrosis in an individual by administering a cell permeable antagonist of inositol polyphosphates to the individual. The invention also provides compositions that are cell permeable agonists of inositol polyphosphates. In addition, the invention provides methods for decreasing chloride ion secretion from a cell by contacting the cell with cell permeable agonists of inositol polyphosphates. The invention also provides methods for decreasing chloride ion secretion in an individual by administering cell permeable agonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with secretory diarrhea in an individual by administering cell permeable agonists of inositol polyphosphates to the individual.