专利检索 ap:("The Regents of the University of California" OR "Shangpharma Innovation Inc.") AND inv:"SHEPPARD, Dean" 第 1 页

1.

发明公开
INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF 审中-公开

公开(公告)号：EP4142707A1

公开(公告)日：2023-03-08

申请号：EP21796020.2

申请日：2021-04-30

申请人： The Regents of the University of California , Shangpharma Innovation Inc.

发明人： SHEPPARD, Dean , DEGRADO, William, F. , SUNDARAM, Aparna , JO, Hyunil , BERESIS, Richard , ADLER, Marc

IPC分类号： A61K31/17 , C07C275/16 , C07C275/24

2.

发明公开
COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH AVB8 INTEGRIN 审中-公开

公开(公告)号：EP4284520A1

公开(公告)日：2023-12-06

申请号：EP22746474.0

申请日：2022-01-25

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean , BIDLINGMAIER, Scott , LIU, Bin , ATAKILIT, Amha

IPC分类号： A61P35/04 , C07K16/28 , C07K16/30

3.

发明公开
INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE 审中-公开

公开(公告)号：EP3765005A1

公开(公告)日：2021-01-20

申请号：EP19766565.6

申请日：2019-03-13

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean , SUNDARAM, Aparna , DEGRADO, William, F. , JO, Hyunil

IPC分类号： A61K31/17 , C07C275/16 , C07C275/24

4.

发明授权
METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH AVB8 INTEGRIN 有权

公开(公告)号：EP2981554B1

公开(公告)日：2020-07-29

申请号：EP14778764.2

申请日：2014-04-01

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean , ATAKILIT, Amha , HENDERSON, Neil Cowan

IPC分类号： C07K16/28

5.

发明公开
ANTI-AVB8 ANTIBODIES AND COMPOSITIONS AND USES THEREOF 审中-公开

公开(公告)号：EP3847194A1

公开(公告)日：2021-07-14

申请号：EP19772925.4

申请日：2019-09-05

申请人： Pfizer Inc. , The Regents of the University of California

发明人： NIESSEN, Kyle, Steven , SAMUEL, Dharmaraj , HOLST, Charles, Ray , DREVER, Matthew, Ross , SHEPPARD, Dean , AKHURST, Rosemary, J. , ATAKILIT, Amha , MEYER, Dominique , RONDON, Isaac, J. , DAL PORTO, Joseph

IPC分类号： C07K16/28 , A61P35/00

6.

发明公开
INHIBITORS OF INTEGRIN ALPHA 5 BETA 1 AND METHODS OF USE 审中-公开

公开(公告)号：EP3436046A2

公开(公告)日：2019-02-06

申请号：EP17776794.4

申请日：2017-03-31

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean , SUNDARAM, Aparna , DEGRADO, William, F. , JO, Hyunil , MCINTOSH, Joel

IPC分类号： A61K38/05 , C07D403/12 , C07D413/12

7.

发明公开
METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH AVB8 INTEGRIN 审中-公开
标题翻译：方法和组合物与AVB8整联蛋白有关的疾病的治疗和预防

公开(公告)号：EP2981554A2

公开(公告)日：2016-02-10

申请号：EP14778764.2

申请日：2014-04-01

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean , ATAKILIT, Amha , HENDERSON, Neil Cowan

IPC分类号： C07K16/28

摘要： Antibodies (e.g., isolated antibodies) that specifically bind to human integrin β8 and inhibit adhesion of latency associated peptide (LAP) to αvβ8 are provided. In some embodiments, the antibody cross-reacts with mouse integrin β8. In some embodiments, the antibody blocks TGFJ3 activation. In some embodiments, the antibody antagonizes binding of LAP to αβ8 with an IC50 below 5 nM.

8.

发明公开
METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH ALPHA V BETA 5 INTEGRIN 有权
标题翻译：方法和组合物用于治疗和预防用αV BETA 5整联蛋白相关疾病的

公开(公告)号：EP1734996A2

公开(公告)日：2006-12-27

申请号：EP05763460.2

申请日：2005-03-30

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean , ATAKILIT, Amha

IPC分类号： A61K39/395 , G01N33/53 , C12N5/20 , C07K16/28

CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/70

摘要： The present invention provides compositions and methods for treating and preventing disease associated with αvß5 integrin by blocking binding to αVβ5 integrin.

9.

发明公开
METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH AVB8 INTEGRIN 审中-公开

公开(公告)号：EP3747907A3

公开(公告)日：2021-02-24

申请号：EP20179661.2

申请日：2014-04-01

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean , ATAKILIT, Amha , HENDERSON, Neil Cowan

IPC分类号： C07K16/28 , A61P11/00 , A61P37/00

摘要： Methods and compositions comprising integrin β8 antibodies are provided.

10.

发明授权
METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH ALPHA V BETA 5 INTEGRIN 有权
标题翻译：治疗和预防与αVβ5整联蛋白相关的疾病的方法和组合物

公开(公告)号：EP2394662B1

公开(公告)日：2018-03-21

申请号：EP11180077.7

申请日：2005-03-30

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean , ATAKILIT, Amha

IPC分类号： A61K39/395 , G01N33/53 , C12N5/20 , C07K16/28 , A61K39/00

CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/70

摘要： The invention provides an antibody that specifically binds to ±v²5 integrin with a K D of 0.01 µM or better. The antibody is useful for treating or preventing diseases such as pulmonary edema.