公开(公告)号：EP1755584A1

公开(公告)日：2007-02-28

申请号：EP05746596.5

申请日：2005-05-09

申请人： The Regents of the University of California ,  The California Institute of Technology

发明人： SCHWARTZ, Daniel, M. ,  YU, Chang, Jun ,  GRUBBS, Robert, H. ,  KORNFIELD, Julia, A. ,  FRASER, Scott, E. ,  MATTSON, Matthew S.

IPC分类号： A61K31/295

CPC分类号： A61K31/135 ,  A61K31/295 ,  A61K31/325 ,  A61K31/37 ,  A61K31/382 ,  A61K31/47 ,  A61K31/495 ,  A61K41/0042 ,  A61K49/0002

摘要： The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment and/or prevention of myopia. An activating energy source is utilized to photopolymerize or crosslink molecules in the sclera, thereby increasing the strength of the tissue. The individual is administered a crosslinking reagent or photopolymerizable molecule that becomes associated with the membrane, which is then precisely exposed to an energy source, such as light or ultrasound.

摘要翻译： 本发明涉及改变眼中至少一个组织的至少一部分的物理和/或化学特性。 在一个具体的实施方案中，它涉及治疗和/或预防近视。 激活能量源被用于使巩膜中的分子光聚合或交联，从而增加组织的强度。 给个体施用与膜相关联的交联试剂或可光聚合的分子，然后将其精确地暴露于能量源如光或超声波。