公开(公告)号：EP3581563A1

公开(公告)日：2019-12-18

申请号：EP19189158.9

申请日：2011-04-11

申请人： The Research Foundation of the State University of New York ,  Syracuse University Technology Transfer And Industrial Development Office

发明人： KERR, William G. ,  CHISHOLM, John D.

IPC分类号： C07C401/00 ,  A61K31/565 ,  A61K31/575 ,  A61K31/56 ,  A61P35/00 ,  C07J31/00 ,  C07J41/00 ,  C07J9/00

摘要： The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP I protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.

公开(公告)号：EP2556055B1

公开(公告)日：2019-07-31

申请号：EP11766857.4

申请日：2011-04-11

申请人： The Research Foundation of the State University of New York ,  Syracuse University Technology Transfer And Industrial Development Office

发明人： KERR, William G. ,  CHISHOLM, John D.

IPC分类号： C07C401/00 ,  A61K31/565 ,  A61K31/575 ,  A61K31/56 ,  A61P35/00 ,  C07J31/00 ,  C07J41/00 ,  C07J9/00

公开(公告)号：EP2556055A2

公开(公告)日：2013-02-13

申请号：EP11766857.4

申请日：2011-04-11

申请人： The Research Foundation of the State University of New York ,  Syracuse University Technology Transfer And Industrial Development Office

发明人： KERR, William G. ,  CHISHOLM, John D.

IPC分类号： C07C401/00 ,  A61K31/565 ,  A61K31/575 ,  A61K31/56 ,  A61P35/00

CPC分类号： C07J41/0005 ,  A61K31/56 ,  A61K31/565 ,  A61K31/575 ,  C07J1/0007 ,  C07J1/0011 ,  C07J9/00 ,  C07J31/003 ,  C07J31/006 ,  C07J41/0011 ,  C07J41/0027 ,  C07J41/005 ,  C07J41/0055

摘要： The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of
ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.