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公开(公告)号：EP2234622A2
公开(公告)日：2010-10-06
申请号：EP08866040.2
申请日：2008-12-29
IPC分类号： A61K31/70
CPC分类号： A61K31/47
摘要： Agonists of AMP-activated protein kinase (AMPK) improve exercise and modify energy metabolism in a subject A combination of AMPK and peroxisome proliferator-activated receptor (PPAR) delta agonists may also be used to improve exercise performance in a subject Methods for identifying substance-enhanced exercise performance in a subject, and methods for identifying compounds that affect the interaction of PPAR6 with exercise-induced kinases are also disclosed.
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2.发明公开
公开(公告)号：EP3578643A1
公开(公告)日：2019-12-11
申请号：EP19175179.1
申请日：2015-03-26
摘要： The invention features compositions comprising in vitro generated beta cells capable of glucose-stimulated insulin secretion, methods of inducing beta cell maturation from embryonic or induced pluripotent stem cell-derived beta-like cells, and methods of using in vitro generated beta cells for treatment of type 1 diabetes, type 2 diabetes, or a related disorder.
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公开(公告)号：EP2114396A2
公开(公告)日：2009-11-11
申请号：EP07870088.7
申请日：2007-12-28
IPC分类号： A61K31/33
CPC分类号： A61K31/426 , A61K31/4178 , A61K31/47 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158
摘要： Disclosed herein are methods for enhancing one or more effects of exercise in a subject by administering a PPARδ agonist {e.g., GW1516) to the subject in combination with an exercise program. Also disclosed are gene expression profiles unique to the combination of agonist-induced PPARδ activation and exercise. Such profiles are useful, at least, in methods for identifying the use of performance-enhancing drugs in exercised subjects (such as, professional or athletes). Direct interactions between PPARδ and exercised-induced kinases {e.g., AMPK or its subunits, AMPK αl and/or AMPK α2) also are disclosed. Such protein-protein interactions provide new targets for identification of useful compounds.
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公开(公告)号：EP3122872B1
公开(公告)日：2019-07-03
申请号：EP15768776.5
申请日：2015-03-26
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5.发明公开COMPOSITIONS AND METHODS FOR TREATING TYPE 1 AND TYPE 2 DIABETES AND RELATED DISORDERS 审中-公开组合物和用于1型糖尿病和2型糖尿病的治疗方法和作者相关疾病
公开(公告)号：EP3122872A1
公开(公告)日：2017-02-01
申请号：EP15768776.5
申请日：2015-03-26
CPC分类号： A61K35/39 , A61K35/12 , A61K35/35 , A61K35/51 , A61K35/545 , A61K38/00 , A61K48/00 , C07K14/70567 , C07K14/721 , C12N5/0676 , C12N15/85 , C12N15/86 , C12N2501/105 , C12N2501/115 , C12N2501/392 , C12N2501/415 , C12N2506/02 , C12N2510/00 , C12N2710/10032 , C12N2710/10043
摘要： The invention features compositions comprising in vitro generated beta cells capable of glucose-stimulated insulin secretion, methods of inducing beta cell maturation from embryonic or induced pluripotent stem cell-derived beta-like cells, and methods of using in vitro generated beta cells for the treatment of type 1 diabetes, type 2 diabetes, or a related disorder.
摘要翻译： 本发明的特征的组合物在能够葡萄糖刺激的胰岛素分泌的体外产生的β细胞，其包括，产生β细胞从胚胎或诱导的多能干细胞衍生的β样细胞，并使用体外的方法诱导的β细胞的成熟的方法，用于治疗 的1型糖尿病，2型糖尿病，或相关病症。
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