公开(公告)号：EP2301959A3

公开(公告)日：2013-03-13

申请号：EP10183197.2

申请日：2003-04-08

申请人： The Scripps Research Institute

发明人： Burton, Dennis ,  Williamson, Anthony ,  Moroncini, Gianluca

IPC分类号： C07K14/47

CPC分类号： C12N15/62 ,  C07K14/47 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2318/10 ,  C07K2319/00 ,  G01N33/6896

摘要： Provided herein are hybrid polypeptides that specifically bind to a disease-associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment, a hybrid protein that specifically binds to the infectious from of a prion (PrP Sc ) is provided.

公开(公告)号：EP2301959A2

公开(公告)日：2011-03-30

申请号：EP10183197.2

申请日：2003-04-08

申请人： The Scripps Research Institute

发明人： Burton, Dennis ,  Williamson, Anthony ,  Moroncini, Gianluca

IPC分类号： C07K14/47

CPC分类号： C12N15/62 ,  C07K14/47 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2318/10 ,  C07K2319/00 ,  G01N33/6896

摘要： Provided herein are hybrid polypeptides that specifically bind to a disease-associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment, a hybrid protein that specifically binds to the infectious from of a prion (PrP Sc ) is provided.

摘要翻译： 本文提供了与涉及蛋白质聚集疾病的多肽的疾病相关同种型特异性结合的杂合多肽。 杂合多肽可用于诊断和治疗这些疾病。 在一个具体实施方案中，提供了与朊病毒（PrP Sc）的感染特异性结合的杂合蛋白。