专利检索 ap:("The Trustees of Columbia University in the City of New York") AND inv:"EDWARDS, John, R." 第 1 页

1.

发明公开
UNIVERSAL METHYLATION PROFILING METHODS 有权
标题翻译：通用甲基化分析方法

公开(公告)号：EP2310401A1

公开(公告)日：2011-04-20

申请号：EP09800674.5

申请日：2009-07-22

申请人： The Trustees of Columbia University in the City of New York

发明人： BESTOR, Timothy, H. , EDWARDS, John, R. , JU, Jingyue , LI, Xiaoxu

IPC分类号： C07H19/16 , A61K31/7076

CPC分类号： C12Q1/6806 , C07H19/23 , C12Q1/6827 , C12Q1/6874 , C12Q2521/125 , C12Q2527/125 , C12Q2537/164

摘要： This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. This invention also provides neobases and methods of sequencing for methylation patterns using neobases.

摘要翻译： 本发明提供衍生双链DNA的方法，包括使双链DNA与CpG甲基转移酶和s-腺苷甲硫氨酸类似物接触。本发明还提供了测序DNA以确定甲基化模式的方法。本发明还提供了使用neobases对甲基化模式进行测序的neobases和方法。

2.

发明授权
UNIVERSAL METHYLATION PROFILING METHODS 有权
标题翻译：通用甲基化分析方法

公开(公告)号：EP2310401B1

公开(公告)日：2015-11-25

申请号：EP09800674.5

申请日：2009-07-22

申请人： The Trustees of Columbia University in the City of New York

发明人： BESTOR, Timothy, H. , EDWARDS, John, R. , JU, Jingyue , LI, Xiaoxu

IPC分类号： C07H19/16 , A61K31/7076 , C12Q1/48 , C12Q1/68 , C07H19/173

CPC分类号： C12Q1/6806 , C07H19/23 , C12Q1/6827 , C12Q1/6874 , C12Q2521/125 , C12Q2527/125 , C12Q2537/164

摘要： This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. This invention also provides neobases and methods of sequencing for methylation patterns using neobases.